A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation (original) (raw)

Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure

Thomas Dieterle

View PDFchevron_right

The Transgenic Expression of Highly Inhibitory Monomeric Forms of Phospholamban in Mouse Heart Impairs Cardiac Contractility

E. Zvaritch

Journal of Biological Chemistry, 2000

View PDFchevron_right

Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction

Arnoud Van Der Laarse

Circulation, 2000

View PDFchevron_right

Effects of Mutant and Antisense RNA of Phospholamban on SR Ca21ATPase Activity and Cardiac Myocyte Contractility

Jody Martin

View PDFchevron_right

Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction : Comparison of a Constitutive Viral Versus an Endothelin-1-Responsive Cardiac Promoter

Heinz-peter Schultheiss

Circulation, 2000

View PDFchevron_right

Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility

Alicia Mattiazzi

Physiological Mini-Reviews, 2010

View PDFchevron_right

Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure

William Louch

Nature Communications, 2022

View PDFchevron_right

Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend

Evangelia Kranias

Journal of molecular and cellular cardiology, 2014

View PDFchevron_right

Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model

Maliha Zahid

Cardiovascular Research, 2004

View PDFchevron_right

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Michael Frisk

Nature Communications

View PDFchevron_right

Cardiac-specific Overexpression of a Superinhibitory Pentameric Phospholamban Mutant Enhances Inhibition of Cardiac Functionin Vivo

Evangelia Kranias

Journal of Biological Chemistry, 2000

View PDFchevron_right

Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport

Evangelia Kranias

AJP: Heart and Circulatory Physiology, 2008

View PDFchevron_right

Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange

Joseph Rabinowitz

AJP: Heart and Circulatory Physiology, 2011

View PDFchevron_right

Immunodetection of Phosphorylation Sites Gives New Insights into the Mechanisms Underlying Phospholamban Phosphorylation in the Intact Heart

Alicia Mattiazzi

Journal of Biological Chemistry, 1996

View PDFchevron_right

Effects of monoclonal antibody against phospholamban on calcium pump ATPase of cardiac sarcoplasmic reticulum

Makoto Inui

Journal of Molecular and Cellular Cardiology, 1991

View PDFchevron_right

Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility

Lai-Hua Xie

Cardiovascular Research, 2011

View PDFchevron_right

Phospholamban: a crucial regulator of cardiac contractility

Evangelia Kranias

Nature Reviews Molecular Cell Biology, 2003

View PDFchevron_right

Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats

Thomas Dieterle

Journal of Clinical Investigation, 2004

View PDFchevron_right

Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation

Peter Backx

Proceedings of the National Academy of Sciences, 2006

View PDFchevron_right

The Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2+-ATPase Superinhibition and Cardiac Remodeling

Anand Pathak

Circulation, 2006

View PDFchevron_right

Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human

Evangelia Kranias

Journal of Clinical Investigation, 2003

View PDFchevron_right

The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in Ca 2+ -sensitivity or myosin ATPase-activity of the contractile proteins

Robert Schwinger

Basic Research in Cardiology, 2000

View PDFchevron_right

Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca 2+ Handling but Exacerbates Cardiac Dysfunction in CaMKIIδ C Transgenic Mice

Evangelia Kranias

Circulation Research, 2010

View PDFchevron_right

Alterations of Phospholamban Function Can Exhibit Cardiotoxic Effects Independent of Excessive Sarcoplasmic Reticulum Ca2+-ATPase Inhibition

Kristina Lorenz, Christine Seidman

Circulation, 2009

View PDFchevron_right

SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts

Demetrios Arvanitis

Physiological Genomics, 2011

View PDFchevron_right