A recombinant antibody increases cardiac contractility by mimicking phospholamban phosphorylation (original) (raw)
Gene transfer of a phospholamban-targeted antibody improves calcium handling and cardiac function in heart failure
Thomas Dieterle
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The Transgenic Expression of Highly Inhibitory Monomeric Forms of Phospholamban in Mouse Heart Impairs Cardiac Contractility
E. Zvaritch
Journal of Biological Chemistry, 2000
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Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction
Arnoud Van Der Laarse
Circulation, 2000
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Effects of Mutant and Antisense RNA of Phospholamban on SR Ca21ATPase Activity and Cardiac Myocyte Contractility
Jody Martin
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Adenovirus-Based Phospholamban Antisense Expression as a Novel Approach to Improve Cardiac Contractile Dysfunction : Comparison of a Constitutive Viral Versus an Endothelin-1-Responsive Cardiac Promoter
Heinz-peter Schultheiss
Circulation, 2000
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Phospholamban: a tiny protein with a prominent role in the regulation of cardiac relaxation and contractility
Alicia Mattiazzi
Physiological Mini-Reviews, 2010
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Blocking phospholamban with VHH intrabodies enhances contractility and relaxation in heart failure
William Louch
Nature Communications, 2022
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Phospholamban interactome in cardiac contractility and survival: A new vision of an old friend
Evangelia Kranias
Journal of molecular and cellular cardiology, 2014
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Phospholamban gene ablation improves calcium transients but not cardiac function in a heart failure model
Maliha Zahid
Cardiovascular Research, 2004
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Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy
Michael Frisk
Nature Communications
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Cardiac-specific Overexpression of a Superinhibitory Pentameric Phospholamban Mutant Enhances Inhibition of Cardiac Functionin Vivo
Evangelia Kranias
Journal of Biological Chemistry, 2000
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Phospholamban overexpression in rabbit ventricular myocytes does not alter sarcoplasmic reticulum Ca transport
Evangelia Kranias
AJP: Heart and Circulatory Physiology, 2008
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Regulation of in vivo cardiac contractility by phospholemman: role of Na+/Ca2+ exchange
Joseph Rabinowitz
AJP: Heart and Circulatory Physiology, 2011
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Immunodetection of Phosphorylation Sites Gives New Insights into the Mechanisms Underlying Phospholamban Phosphorylation in the Intact Heart
Alicia Mattiazzi
Journal of Biological Chemistry, 1996
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Effects of monoclonal antibody against phospholamban on calcium pump ATPase of cardiac sarcoplasmic reticulum
Makoto Inui
Journal of Molecular and Cellular Cardiology, 1991
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Ablation of phospholamban and sarcolipin results in cardiac hypertrophy and decreased cardiac contractility
Lai-Hua Xie
Cardiovascular Research, 2011
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Phospholamban: a crucial regulator of cardiac contractility
Evangelia Kranias
Nature Reviews Molecular Cell Biology, 2003
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Chronic phospholamban inhibition prevents progressive cardiac dysfunction and pathological remodeling after infarction in rats
Thomas Dieterle
Journal of Clinical Investigation, 2004
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Cardiac-specific overexpression of sarcolipin in phospholamban null mice impairs myocyte function that is restored by phosphorylation
Peter Backx
Proceedings of the National Academy of Sciences, 2006
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The Presence of Lys27 Instead of Asn27 in Human Phospholamban Promotes Sarcoplasmic Reticulum Ca2+-ATPase Superinhibition and Cardiac Remodeling
Anand Pathak
Circulation, 2006
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Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human
Evangelia Kranias
Journal of Clinical Investigation, 2003
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The enhanced contractility in phospholamban deficient mouse hearts is not associated with alterations in Ca 2+ -sensitivity or myosin ATPase-activity of the contractile proteins
Robert Schwinger
Basic Research in Cardiology, 2000
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Phospholamban Ablation Rescues Sarcoplasmic Reticulum Ca 2+ Handling but Exacerbates Cardiac Dysfunction in CaMKIIδ C Transgenic Mice
Evangelia Kranias
Circulation Research, 2010
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Alterations of Phospholamban Function Can Exhibit Cardiotoxic Effects Independent of Excessive Sarcoplasmic Reticulum Ca2+-ATPase Inhibition
Kristina Lorenz, Christine Seidman
Circulation, 2009
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SERCA2a superinhibition by human phospholamban triggers electrical and structural remodeling in mouse hearts
Demetrios Arvanitis
Physiological Genomics, 2011
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