Early outcome of tetralogy of Fallot repair in the (original) (raw)
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Early outcome of tetralogy of Fallot repair
Journal of the Saudi Heart Association
Abstract Background: Traditional use of trans-annular patch (TAP) to release right ventricular outflow tract (RVOT) obstruction during tetralogy of Fallot (TOF) repair may lead to a harmful pulmonary regurgitation. Different approaches have been used to release RVOT obstruction and spare the pulmonary valve (PV) function. In this study, we aim to evaluate the post-operative course of patients who had TOF repair in the current era that emphasizes on protective strategy of releasing RVOT obstruction and preserving PV function. Methods: A retrospective study of all TOF cases repaired in our institute between March 2002 and December 2007 was conducted. Cases were classified into two groups; group I included patients that had a TAP, while group II included cases that had simple TOF repair without TAP. Group I was subdivided into two groups, group (A) which include patients who had TAP without a valve. Group (B) includes those who had TAP with a monocuspid valve (Contegra). We compared po...
Early outcome of tetralogy of Fallot repair in the current era of management
Journal of the Saudi Heart Association, 2010
Background: Traditional use of trans-annular patch (TAP) to release right ventricular outflow tract (RVOT) obstruction during tetralogy of Fallot (TOF) repair may lead to a harmful pulmonary regurgitation. Different approaches have been used to release RVOT obstruction and spare the pulmonary valve (PV) function. In this study, we aim to evaluate the post-operative course of patients who had TOF repair in the current era that emphasizes on protective strategy of releasing RVOT obstruction and preserving PV function.
2021
Objective: To compare the early operative outcome of TOF repair with three contemporary repair strategies of RVOTO repair i.e. TAP, Mono-cusp construction (MC) in TAP and pulmonary valve repair. Methods: Study is performed at Punjab Institute of Cardiology, Lahore from May 2016 to April 2020. Retrospective analysis of data was performed for patient who underwent TOF repair by three different strategies of RVOT repairs during TOF surgery based on z scoring for pulmonary valve annulus. Group-I underwent trans-annular patch repair, while Group-II and III underwent Mono-cusp repair with autologous pericardium and pulmonary valve repair respectively. Analysis of Variance (ANOVA) and Pearson Chi-Square (PCS) statistics were used to compare the three groups for numeric and categorical variables respectively. Post-hoc t-test and Bonferroni correction were performed for numeric data to compare two groups with each other. Chi-square test was used to perform comparison between groups for categ...
Circulation journal : official journal of the Japanese Circulation Society, 2018
We reviewed our revised surgical strategy for tetralogy of Fallot (TOF) total correction to minimize early exposure to significant pulmonary regurgitation (PR) and to avoid right ventriculotomy (RV-tomy). Methods and Results: Since February 2016, we have tried to preserve, first, pulmonary valve (PV) function to minimize PR by extensive commissurotomy with annulus saving; and second, RV infundibular function by avoiding RV-tomy. With this strategy, we performed total correction for 50 consecutive patients with TOF until May 2018. We reviewed the early outcomes of 27 of 50 patients who received follow-up for ≥3 months. Mean patient age at operation was 10.2±5.0 months, and mean body weight was 8.8±1.2 kg. The preoperative pressure gradient at the RV outflow tract and the PV z-score were improved at most recent echocardiography from 82.0±7.1 to 26.8±6.4 mmHg, and from -2.35±0.49 to -0.55±0.54, respectively, during 11.1±1.6 months of follow-up after operation. One patient required re-i...
Korean Circulation Journal, 2021
Background and Objectives: We reviewed the long-term outcomes after tetralogy of Fallot (TOF) repair with trans-annular incision; and evaluated the effectiveness of pulmonary valve replacement (PVR) on outcomes. Methods: This was a retrospective review of clinical outcomes of 180 of 196 TOF patients who underwent total correction with trans-annular incision from 1991 to 1997 (PVR group: 81; non-PVR group: 99). Results: The median age of the patients was 14.0 months (interquartile range [IQR], 10.7-19.8 months) at TOF repair. Ten in-hospital deaths (5.1%) occurred. During the followup, 81 patients underwent PVR at the median age of 13.5 years (IQR, 11.2-17.1 years). The patients in PVR group showed better outcomes than non-PVR group in overall survival rate (100% in PVR vs. 88.7% in non-PVR, p=0.007), in all adverse events (arrhythmia, neurologic complications, 95.5% in PVR vs. 74.6% in non-PVR, p=0.024) at 20 years. Age at TOF repair younger than 1 year (hazard ratio [HR], 2.265; p=0.01) and previous shunt history (HR, 2.195; p=0.008) were predictive for requiring PVR. During follow-up, 10 late deaths (5 sudden deaths) occurred in the non-PVR group, mainly due to ventricular arrhythmia and right ventricular failure; there was 1 late death (not a sudden death) in the PVR group. Conclusions: Long-term survival after repair of TOF with trans-annular incision were acceptable. However, arrhythmias were frequently observed during 20 years of follow-up. The patient age <1 year at the time of TOF repair and shunt implantation prior to TOF repair were predictive factors for requiring PVR.
Pulmonary valve replacement in primary repair of tetralogy of Fallot in adult patients
Journal of Thoracic Disease
Background: Adults with unrepaired tetralogy of Fallot (ToF) are common in developing countries. Longterm overload of the right ventricle places adult patients at risk for postoperative right heart failure after primary repair, which contributes to morbidity and mortality. The effect of pulmonary valve replacement (PVR) in reducing postoperative morbidity and mortality in adults has never been validated. Methods: We conducted a retrospective cohort study in adults (age ≥18 years) with ToF undergoing primary repair from January 2014 to December 2019 at our institution. Patients were divided into three groups according to techniques used to enlarge the right ventricle outflow tract (RVOT). Baseline variables and perioperative outcomes were collected. The primary endpoint was operative mortality. Secondary endpoints were incidences of right heart failure and stage 3 acute kidney injury (AKI). Results: A total of 56 patients were enrolled (mean age 41.5±11.7 years, 30 females, 53.6%). They were divided into three groups designated as the following: TA-PVR group for trans-annular patch enlargement with PVR; TA group for trans-annulus patch enlargement without PVR; and group AP for annulus preservation. Four patients (7.1%) died postoperatively, all due to right heart failure. All twelve patients in the TA-PVR group survived. There was no significant difference in mortalities among groups. Ten patients (17.9%) developed right heart failure after surgery with no significant difference among groups. Three patients (5.4%) developed stage 3 AKI after surgery, none belonging to the TA-PVR group, however, not statistically significant. Conclusions: Right heart failure is a common complication after primary repair of adult ToF. Transannulus patch enlargement should be cautiously selected in this population. PVR with trans-annulus patch enlargement may be a promising technique to protect against postoperative right heart failure and mortality when annulus preservation is not feasible.
Objective: To describe the anatomy of the PV in tetralogy of Fallot (TOF) and to define the influence of PV anatomy on the development of surgical techniques for PV preservation during early repair. Methods: The PV was evaluated in 79 anatomic specimens of patients with TOF who had not undergone surgery for repair, and in 82 patients who underwent early TOF repair at our institution. New surgical techniques for PV preservation during early repair are described. Results: The PV in TOF was predominantly bicuspid (n ¼ 118 of 160; 73.7%), less frequently tricuspid (n ¼ 28 of 160; 17.5%), and seldom unicuspid (n ¼ 14 of 160; 8.8%). In 82 cases (51.3%), the PV cusps were normal; in 78 cases (48.7%), they were thickened and dysplastic. Preservation of the PV was possible in 46 of 82 (56%) consecutive patients during TOF repair in our more recent experience, either using balloon dilation alone (18 of 46; 39%) or in association with other PV plasty procedures (28 of 46; 61%). Most bicuspid and tricuspid valves were salvageable, but unicuspid valves were not suitable. After a median follow-up time of 2.8 years (range, 0.5-6.8 years), the degree of PV regurgitation continued to be zero or mild in 40 patients (86%), and moderate in 6 (14%). Conclusions: The majority of patients with TOF (>90%) have a bicuspid or tricuspid PV, which is the most favorable surgical anatomy for preserving the PV, independent of the degree of leaflet dysplasia. The recent introduction of more-complex PV plasty techniques, such as delamination plasty, allowed us to further extend the applicability of PV-preservation techniques. (J Thorac Cardiovasc Surg 2015;149:1358-63) Supplemental material is available online. Continuous improvements in surgical technique and post-operative management have made repair of tetralogy of Fallot (TOF) feasible in early infancy, with low risk. 1-5 Despite awareness of the late consequences of pulmonary valve (PV) regurgitation, 6-8 transannular patching of the right ventricular outflow tract (RVOT) remains the most prevalent technique for TOF repair. 1,2 Techniques have been developed to avoid a large ventriculotomy during TOF repair, and recently, interest has shifted to preserving the integrity of the PV annulus, thus avoiding PV regurgitation. 9-16 We undertook an analysis of the anatomy of the PV in TOF, to support efforts to develop new surgical PV-preservation techniques. METHODS For the review of medical records, and the use of computerized hospital data, which was approved by the Clinical Investigation Committee of the University Hospital of Padua, the procedures followed were in accordance with the institutional guidelines for retrospective record review and protection of patient confidentiality. Patients were not identified, and the chairperson of the Ethics Committee gave consent for the patients' data to be submitted for publication. We enrolled all patients who underwent TOF repair with intraoperative PV preservation at our institution since June 2007. Patients were excluded if they: had mild forms of TOF and did not require surgical manipulation of the PV; had TOF with severe PV stenosis and diminutive pulmonary artery branches with aorto-pulmonary collaterals and were treated by right ventricle–pulmonary artery conduit interposition; or had TOF with absent PV or double-outlet right ventricle. Patients who were followed for <6 months after surgery were excluded from the analysis (n ¼ 4 patients who underwent PV preservation). In addition, 2 patients were excluded who required a reoperation for residual RVOT obstruction after the initial repair (1, the first in our experience, underwent an initial PV preservation, and the other underwent surgery for a transannular patch). The PV-preservation technique by intraoperative balloon dilation during early repair of TOF has been previously described. 10,11 When the PV effective orifice is particularly narrow (z-score < À3), additional surgical procedures on the PV are usually required after dilatation, to achieve valve competence. Usually the repair and resuspension of the PV leaflet
Journal of Cardiothoracic Surgery
Background: Right ventricular (RV) volume overload increases morbidity and mortality after tetralogy of Fallot (TOF) repair. Surgical strategies like pulmonary leaflets sparing and tricuspid valve repair at time of primary repair may decrease RV overload. Our objective is to evaluate early and midterm results of pulmonary leaflets sparing with infundibular preservation and tricuspid valve repair in selected TOF patients with moderate pulmonary annular hypoplasia. Methods: From 2011 to 2016; 46 patients with TOF and moderate pulmonary annular hypoplasia had surgical repair with sparing of the pulmonary valve leaflets. Concomitant tricuspid valve repair was performed in 33 patients (71.8%). Mean age was 13.1 ± 4.8 months, 68% were males (n = 31) and mean weight was 9.5 ± 2.3 kg. Preoperative McGoon ratio was 1.9 ± 0.4 and pulmonary valve z-score ranges from − 2 to − 3. Preoperative pressure gradient of RVOT was 80.9 ± 7.7 mmHg and 10.9% had minor coronary anomalies (n = 5). Results: All repairs were performed through trans-atrial trans-pulmonary approach. 87% had pulmonary valve commissurotomy (n = 40). Mean cardiopulmonary bypass time was 71 ± 6.3 min and ischemic time 42.4 ± 4. 9 min. Hospital mortality occurred in 4.3% (n = 2). Mean RVOT pressure gradient decreased significantly postoperatively (28.8 ± 7.2 mmHg, p-value< .001) and at the last follow up (23.6 ± 1.8 mmHg, p-value< .001). Pulmonary regurgitation progressed by one grade in 2 patients compared to the postoperative grade. 1 patient (2.5%) had late mortality and reintervention was required in 5 patients (12.5%). Conclusion: Pulmonary leaflets sparing, and tricuspid valve repair are safe for TOF repair with no added morbidity or mortality. These procedures could contribute to reducing right ventricular volume overload over time after TOF repair.
Pakistan Postgraduate Medical Journal
Objectives: To determine the immediate and early outcome of pulmonary valve cusp augmentation for repair of tetralogy of Fallot (TOF) Methods: A descriptive study of 36 cases of TOF repair done from July 2020 to December 2022 at Faisalabad Institute of cardiology (FIC). Autologous pericardium used in all cases to augment the pulmonary valve cusp to increase the size of pulmonary valve orifice. Patients were followed in immediate and early post operative period by doing echocardiography to observe the outcome including pulmonary valve regurgitation (PR), stenosis and right ventricular outflow tract obstruction (RVOTO) Results: Median age was 12 years (4–21). Immediate Post repair echocardiography showed no PR in 77.8 % of patients (n=28) while 8 patients had mild PR (22.2%). Majority of patients (61.1%) had mild RVOT obstruction, 13 patients (36.1%) had moderate RVOT obstruction while one patient had severe RVOT obstruction. Mean gradient across RVOT was 36.72 (+/- 11.08). The data ...