Epstein-Barr virus is associated with gastric carcinoma: The question is what is the significance? (original) (raw)
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Epstein-Barr Virus-Associated Gastric Carcinoma and Atrophic Gastritis
Journal of Clinical Gastroenterology, 1999
To investigate the incidence of Epstein-Barr virusassociated gastric cancer (EBV-GC) in Kazakhstan and to compare it with that in Russia, Western and Asian countries in order to evaluate the significance of epidemiopathologic and ethnic factors.
2009
Objectives. To determine the association of Epstein-Barr Virus in gastric tumours in the Kingdom of Bahrain and to explore its role in tumour pathogenesis. Method. A reterospective study was performed including 58 cases of gastric tumours between January 2001 till December 2005 received in Histopathology department Salmaniya Medical Complex, Kingdom of Bahrain. These cases consist of carcinomas, carcinoids and lymphomas. Formalin fixed tissue sections were used to perform immunohistochemistry and InSitu Hybridization using Anti-EBV-LMP (Latent Membrane Protein) antibodies and EBER PNA probe respectively. Results.- The EBV-RNA expression was detected in 44.40% of the intestinal type adenocarcinomas, 25% signet ring cell type adenocarcinomas, 100% carcinoid tumours and 50% lymphomas (p value < 0.036). Tumours showing positive staining pattern for EBER PNA probe were also positive for EBV-LMP except the carcinoid tumours. Of the EBV positive carcinoma cases 75% were poorly different...
Association of a distinctive strain of Epstein-Barr virus with gastric cancer
International Journal of Cancer, 2006
Epstein-Barr virus (EBV) has been associated with the most common form of stomach neoplasms, the gastric carcinoma (GC). The presence of EBV-encoded small RNAtype-1 (EBER-1), a marker for EBV infection was analyzed by in situ hybridization (ISH) in 185 formalin-fixed and paraffinembedded cases of GC from a high risk region. We found 31 (16.8%) EBV-positive cases with no relationship to age. Although male predominance (19% in males and 12.5% in females) was observed, the gender difference did not achieve statistical significance. Odds ratio (OR) for cardia location was 5.4 (95% CI 1.7-17.3) when antrum was used as referent category and the effects of gender and age were taken into account. The proportion of EBV-positive cases in diffuse histology was higher than intestinal type (OR ؍ 4.8, 95% CI ؍ 2.0 -11.1). Our findings are contrary to a previously accepted hypothesis, that high-risk countries for GC have low rates of EBV-associated GC. In addition, our findings regarding location, histology and weak male predominance are different from what has been described in Asian and European countries, but similar to those described in Mexico and Mexican descendants living in the U.S. suggesting unique characteristics of EBV-associated GC in Latin-America.
Prevalence of Gastric Cancer Associated with the Epstein-Barr Virus at Brazzaville Chu
https://www.ijhsr.org/IJHSR\_Vol.11\_Issue.9\_Sep2021/IJHSR-Abstract.021.html, 2021
Introduction: Several studies have shown an association between infection with Epstein-Barr virus (EBV) and the occurrence of many cancers in humans, including certain gastric carcinomas (GC). Indeed, recent studies have reported that 10% of CGs are associated with EBV. Materials and Methods: Samples of gastric carcinomatous tissues (biopsies and surgical specimens) were analyzed by PCR for the detection of EBV. Samples were collected retrospectively between January 2008 and December 2018. Results: during this period, 52 samples were analyzed. PCR results show the EBV infection rate to be 3.8%. Conclusion: The results obtained during this preliminary study confirm the association of EBV in 3.8% of CG cases, which is consistent with the data in the literature.
Journal of Experimental & Clinical Cancer Research, 2009
Background Epstein-Barr virus (EBV) has been shown to be associated with gastric cancer. However, inconsistent findings have been reported regarding the distribution of EBV infected cells (in normal gastric epithelium vs. intestinal metaplastic cells vs. in neoplastic cells) and the characteristics of EBV-associated gastric cancer. Lymph node positive EBV-associated gastric cancer has not been systematically studied. The aims of this study were to evaluate EBV-associated gastric cancer, to assess the distribution of EBV infected cells including all positive lymph nodes, and to define the characteristics of EBV-associated gastric cancer. Design The study included primary gastric cancer patients who underwent surgical resection with no preoperative treatment at M.D. Anderson Cancer Center between 1987 and 2006. Formalin-fixed paraffin-embedded tissue from these resection specimens were assessed for EBV by in situ hybridization, the gold standard for EBV detection in tissue. EBV status was analyzed along with clinicopathologic parameters including age, gender, tumor type, lymph node status, and pathologic stage of the tumor. Results Among 235 patients, 12 had intranuclear expression of EBV. EBV staining was seen only in tumor cells and no detectable EBV was observed in normal gastric mucosa, intestinal metaplasia or stromal cells. Eight of 12 patients with EBV-associated gastric cancer had regional lymph node metastasis. Of note, metastatic tumor cells in all of the involved lymph nodes of these 8 cases contained EBV. The epidemiologic data showed 11 of the 12 patients with EBV-associated gastric cancer were men, ranging in age from 54 to 78 years (mean age, 60 years; median age, 62.1 years). The age distribution for non-EBV associated gastric cancer patients ranged from 21 to 93 years (mean age, 67 years; median age, 66.4 years). Conclusion Our study demonstrated that EBV is present exclusively in gastric cancer cells. The detection of EBV in tumor cells in all of the lymph nodes involved with metastatic gastric carcinoma suggests simultaneous replication of EBV and tumor cells. The predominantly male gender and relatively younger age observed for the EBV-infected gastric cancer cases suggest an association between this disease and other factors, such as life style.
Epstein-Barr virus and carcinomas: rare association of the virus with gastric adenocarcinomas
British journal of …, 1993
We have analysed 174 gastric carcinomas from the United Kingdom and from Japan for the presence of Epstein-Barr virus (EBV) using in situ hybridisation for the small EBV-encoded nuclear RNAs (EBERs). EBV was detected in the tumour cells in all of six undifferentiated gastric carcinomas with prominent lymphoid stroma (undifferentiated carcinomas of nasopharyngeal type, UCNT) but only in three of the remaining 168 typical gastric adenocarcinomas (1.8%). No differences were observed between the British and the Japanese cases. One case with an EBV-positive UCNT showed adjacent areas of EBV-negative typical adenocarcinoma. It is uncertain whether these patterns represent two independent carcinomas or whether they are the result of heterogenous EBV infection in a single tumour. In the remaining EBV-positive carcinomas, viral transcripts were detected in virtually all tumour cells, indicating that EBV infection must have taken place early in the neoplastic process and suggesting that the virus is likely to be of pathogenetic significance for the virus-associated tumours. Immunohistology demonstrated absence of detectable levels of the EBV-encoded latent membrane protein, LMPI, and nuclear antigen, EBNA2. The BZLFI protein which induces the switch from latent to lytic infection was demonstrated in a small proportion of the tumour cells in three cases. The close association of EBV with undifferentiated gastric carcinomas compared to the variable association with gastric adenocarcinomas suggests fundamentally different roles for the virus in the aetiology of these two malignancies.
Open Access Macedonian Journal of Medical Sciences
BACKGROUND AND AIM: Gastric cancer (GC) is one of the top causes of cancer-related deaths worldwide. According to the Cancer Genome Atlas, there are four subtypes of GC, with the Epstein-Barr virus (EBV) subtype accounting for about 10% of cases. EBV infection causes EBV-associated GC (EBVaGC). The previous research suggested that the presence of the EBV viral genome in gastric carcinomas could be used as a surrogate marker for targeted therapy and optimal GC treatment. AIM: We aimed to explore the rate of EBV involvement in gastric carcinogenesis from molecular perspective view and to evaluate the role of the tumor-suppressor protein p16 as a marker for diagnosis in GC Egyptian patients in relation to EBV infection. METHODS: One hundred-four surgically resected GC cases were analyzed. Two methods including quantitative real-time polymerase chain reaction (qPCR) for detecting EBV-derived latent membrane protein-1 (LMP-1) and Epstein-Barr nuclear antigen-1 (EBNA-1) genes as well as i...
IRJPMS, 2024
Background: New horizons are opened for the treatment of Epstein-Barr Virus (EBV)-positive gastric cancers, however, specific clinicopathological characteristics have not been identified in addition to ethnic and geographical incidence variation. Aim: In this study, we investigated the prevalence of EBV-positive gastric cancer in a sample of Iraqi patients and evaluated the clinicopathological correlation. Materials and Methods: Thirty formalin fixed paraffin embedded primary adenocarcinoma were retrieved from the archives of the Department of Pathology at Baghdad Teaching Hospital. Demographics and histopathological data were collected from patients' records. EBV-DNA was targeted by an in-situ hybridization technique. Results: the mean age of the patients was 55.8± 13.39 years, with a range of 30-80 years. The male-to-female ratio is 1.3:1. EBV was detected in 8 (26.6%) cases. EBV-positive gastric carcinoma did not exhibit any demographically significant variations. Although 5 (62.7%) of the EBV-positive tumors were of intestinal type, 6 (75%) were antral/pyloric and 6 (75%) were advanced stage, these characteristics did not differ significantly from those of the EBV-negative tumors. Conclusions: the prevalence of EBV gastric cancer is relatively high. Association with histopathologic type, anatomical site, and tumor stage did not reach statistically significant warranting larger multicentric study.
International journal of cancer. Journal international du cancer, 2001
Epstein-Barr virus (EBV) has been associated with the most common form of stomach neoplasms, the gastric carcinoma (GC). The presence of EBV-encoded small RNAtype-1 (EBER-1), a marker for EBV infection was analyzed by in situ hybridization (ISH) in 185 formalin-fixed and paraffin-embedded cases of GC from a high risk region. We found 31 (16.8%) EBV-positive cases with no relationship to age. Although male predominance (19% in males and 12.5% in females) was observed, the gender difference did not achieve statistical significance. Odds ratio (OR) for cardia location was 5.4 (95% CI 1.7-17.3) when antrum was used as referent category and the effects of gender and age were taken into account. The proportion of EBV-positive cases in diffuse histology was higher than intestinal type (OR = 4.8, 95% CI = 2.0-11.1). Our findings are contrary to a previously accepted hypothesis, that high-risk countries for GC have low rates of EBV-associated GC. In addition, our findings regarding location,...