Age-adjusted hsTnT cut-off value for risk stratification of pulmonary embolism (original) (raw)

The European respiratory journal, 2015

Abstract

High-sensitivity troponin T (hsTnT) helps in identifying pulmonary embolism patients at low risk of an adverse outcome. In 682 normotensive pulmonary embolism patients we investigate whether an optimised hsTnT cut-off value and adjustment for age improve the identification of patients at elevated risk. Overall, 25 (3.7%) patients had an adverse 30-day outcome. The established hsTnT cut-off value of 14 pg·mL(-1) retained its high prognostic value (OR (95% CI) 16.64 (2.24-123.74); p=0.006) compared with the cut-off value of 33 pg·mL(-1) calculated by receiver operating characteristic analysis (7.14 (2.64-19.26); p<0.001). In elderly (aged ⩾75 years) patients, an age-optimised hsTnT cut-off value of 45 pg·mL(-1) but not the established cut-off value of 14 pg·mL(-1) predicted an adverse outcome. An age-adjusted hsTnT cut-off value (⩾14 pg·mL(-1) for patients aged <75 years and ⩾45 pg·mL(-1) for patients aged ⩾75 years) provided additive and independent prognostic information on to...

david jimenez hasn't uploaded this paper.

Let david know you want this paper to be uploaded.

Ask for this paper to be uploaded.