The molecular and cellular biology of human herpesvirus—6 (original) (raw)

A REVIEW ON HUMAN HERPESVIRUSES

In our lifetime we will experience no less than one if not a few human herpesviruses. These viruses evoke a solid immune response upon essential infection. Be that as it may, this immune response can't clear the virus because of its immune equivocal properties. Rather, it drives the virus into a dormant state. In sound people these viruses are considered genuinely safe, though in immune-compromised people they are related with the beginning of genuine diseases. These inconveniences and the distress which can be related with infection are solid inspirations for vaccine advancement. By checking on the clinically most significant herpesviruses a general example rose concerning the issues experienced amid vaccine advancement. Furthermore, people experience some herpesviruses before their first birthday celebration which confounds inoculation against an essential infection. Besides inoculating against essential infections, another methodology is immunized against confusions related with reactivation or immune deficiency. This field is considerably all the more difficult, it appears to be improbable one can support an inadequate immune framework. In this paper a review of the immune response, the immune evasion properties and the status of vaccine improvement is accommodated the clinically most significant human herpesviruses.

Antigenic relationships among human herpesvirus-6 isolates

Journal of Medical Virology, 1992

Human herpesvirus 6 (HHV-6) prototype isolate G S is a newly identified lymphotropic herpesvirus and several subsequent herpes isolates were recoanized as HHV-6 bv their hvbridization to a KEY WORDS: antigenic variations, reactivity of human sera, HHV-6 HHVr6(GS) DNA probe pZVH14.'DNA restriction analysis and in vitro tropism studies show that 0 1992 WILEY-LISS, INC.

HIV infection and HERV expression: a review

Retrovirology, 2012

The human genome contains multiple copies of retrovirus genomes known as endogenous retroviruses (ERVs) that have entered the germ-line at some point in evolution. Several of these proviruses have retained (partial) coding capacity, so that a number of viral proteins or even virus particles are expressed under various conditions. Human ERVs (HERVs) belong to the beta-, gamma-, or spuma-retrovirus groups. Endogenous delta-and lenti-viruses are notably absent in humans, although endogenous lentivirus genomes have been found in lower primates. Exogenous retroviruses that currently form a health threat to humans intriguingly belong to those absent groups. The best studied of the two infectious human retroviruses is the lentivirus human immunodeficiency virus (HIV) which has an overwhelming influence on its host by infecting cells of the immune system. One HIV-induced change is the induction of HERV transcription, often leading to induced HERV protein expression. This review will discuss the potential HIV-HERV interactions. Several studies have suggested that HERV proteins are unlikely to complement defective HIV virions, nor is HIV able to package HERV transcripts, probably due to low levels of sequence similarity. It is unclear whether the expression of HERVs has a negative, neutral, or positive influence on HIV-AIDS disease progression. A positive effect was recently reported by the specific expression of HERVs in chronically HIV-infected patients, which results in the presentation of HERV-derived peptides to CD8 + T-cells. These cytotoxic T-cells were not tolerant to HERV peptides, as would be expected for self-antigens, and consequently lysed the HIV-infected, HERV-presenting cells. This novel mechanism could control HIV replication and result in a low plasma viral load. The possibility of developing a vaccination strategy based on these HERV peptides will be discussed.

Summary of Informal Discussion on General Aspects of Herpesviruses

Cancer Research, 1973

Dr. Spiegelman opened the discussion by asking Dr. Roizman two questions: one, what was the actual concen tration of the DNA in the reaction mixture; for that is the key to interpreting the kinetic curves, as it is necessary to know the C0l value that was actually measured. The other question was where are the controls, how many normal DNA's have been examined in the same way, and is there any hybridization with DNA from normal uteri.