High-throughput automated system for statistical biosensing employing microcantilever arrays (original) (raw)
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IJERT-Design of A Micro-Cantilever Biosensor for Micro-Level Detections
International Journal of Engineering Research and Technology (IJERT), 2020
https://www.ijert.org/design-of-a-micro-cantilever-biosensor-for-micro-level-detections https://www.ijert.org/research/design-of-a-micro-cantilever-biosensor-for-micro-level-detections-IJERTV9IS080208.pdf A modern approach for the creation of nanomechanical-based biosensors is the surface immobilization of functional receptors in microfabricated cantilevers arrays. Microcantilever-based systems can identify unlabeled diseases in very limited quantities of samples in real-time and multiplexed ways. The processing technologies presently available would enable the incorporation and analysis of one piece of equipment, reducing the size of the device, detection time, and expenses. Microfabricated cantilever array-based biosensing systems, requiring numerous cantilevers, electronic processing, and even local telemetry on a single device, can address the extremely responsive and limited multi-target detection needs for very small samples. Here we discuss the design and development cycle of biosensors based on the cantilever.
Microcantilever Array Sensors for Biomolecular Detection
2005
Microcantilever based sensors are a new class of extremely sensitive sensor device that is currently being developed for chemical and biological detection. In the work described here, Oligonucleotide probes for DNA and mRNA were immobilized on the gold coated side of silicon microcantilevers via thiol linkers and exposed to complementary and non-complementary sequences using microliter volumes of sample solutions. The surface stress generated by specific recognition between complementary sequences could be monitored as it induced a deflection of the cantilever. The deflection response of up to sixteen cantilevers could be read in parallel using a new optical reader based on an array of laser diodes (VCSELs). As a model system for affinity binding, biotin-streptavidin interaction was also monitored against unspecific streptavidin adsorption
International Journal of Engineering Development and Research, 2014
1 Research scholar, 2 Professor & HOD 1 Electronics Department Sathyabama University, Chennai, India 2 I&C Department, SRM University,Chennai,India vikas_selvan@yahoo.co.in ________________________________________________________________________________________________________ Abstract—This paper deals with a biosensor using a micro fabricated array of micromechanical cantilevers. This biosensor is used to detect tuberculosis. The sensor consists of antibody layer immobilized onto gold-coated cantilevers and interacts with antigen. The patient blood sample is placed on the cantilever surface. If the sample contains disease causing antigen, immobilized antibody binds with the antigen. This antigen antibody binding causes increase in surface stress. The addition of mass due to antigen antibody binding involved in this process causes the cantilever to bend. The deflection of these cantilever beams can be detected using various techniques like piezoresistive, piezoelectric or capacitive...