High-Frequency Oscillatory Ventilation versus Conventional Mechanical Ventilation for Very-Low-Birth-Weight Infants (original) (raw)

2002, New England Journal of Medicine

AI-generated Abstract

High-frequency oscillatory ventilation (HFOV) and synchronized intermittent mandatory ventilation (SIMV) were compared in a randomized clinical trial involving very-low-birth-weight infants (601 to 1200 g). Results showed that infants on HFOV were extubated earlier and had a 56% survival rate without supplemental oxygen at 36 weeks, compared to 47% in the SIMV group. Despite these positive outcomes, there were no significant differences in serious complications like intracranial hemorrhage and cystic periventricular leukomalacia between the two ventilation methods, suggesting that HFOV may offer some benefits for this vulnerable population.