Inhibitory Activity on cAMP Phosphodiesterase of Some Cembranoids (original) (raw)

Cembranoid diterpenes, namely, crotocembraneic acid (1), neocrotocembraneic acid (2), poilaneic acid , as well as their synthetic derivatives including methyl crotocembraneate (1a), crotocembranol (1b), crotocembranal (1c), methyl neocrotocembraneate (2a), neocrotocembranol (2b), neocrotocembranal (2c), methyl poilaneate (3a), poilaneol (3b) and poilanal (3c), were evaluated for their inhibitory activity against cAMP phosphodiesterase. Cembranoids with carboxylic acid functional groups showed higher inhibitory activity than those with other functionalities in the following order: carboxylic acid, hydroxyl, methyl ester and aldehyde.