Preparation of Synthetically Challenging Nucleotides Using Cyanoethyl P-Imidazolides and Microwaves (original) (raw)

Organic Letters, 2012

Abstract

We describe a general method for the elongation of nucleoside oligophosphate chains by means of cyanoethyl (CE) phosphorimidazolides. Though the method requires a phosphorylation and subsequent deprotection reaction, both steps could be achieved in one pot without isolation/purification of the initial phosphorylation product. We have also found that pyrophosphate bond formation by this method is significantly accelerated by microwave irradiation.

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