Ethnobotany, Phytochemistry and Pharmacology of Uncaria (Rubiaceae) (original) (raw)
Related papers
American Journal of Biomedical and Life Sciences, 2013
A good understanding of a medicinal plant is based on fundamental knowledge of its chemical constituents and their pharmacological effects. The non-alkaloids constituents isolated from Uncaria species have been increasingly investigated recently. The anti-inflammatory, anti-oxidant and anti-cancer properties have been studied in many non-alkaloids constituents isolated from Uncaria species. This paper emphasizes the phytochemical and chemotaxonomic analyses of non-alkaloid constituents isolated from fifteen Uncaria species. Their structural activity-relationships have also been discussed.
Anti-inflammatory activity of two different extracts of Uncaria tomentosa (Rubiaceae)
Journal of Ethnopharmacology, 2002
We assessed in vivo the anti-inflammatory activity of two Cat's claw bark extracts, by comparing a spray-dried hydroalcoholic extract against an aqueous freeze-dried extract, to determine which extract was more effective. We used the carrageenan-induced paw edema model in mice. In addition, to assess the molecular mechanism of action, we determined the inhibition of NF-κB through the Electrophoretic Mobility Shift Assay (EMSA) and the effects on cycloxygenase-1 and -2. Results showed that the anti-inflammatory activity was significantly higher using the hydroalcoholic compared with the aqueous extract (P<0.05). The extracts also showed little inhibitory activity on cyclooxygenase-1 and -2. It cannot be excluded that the slight inhibitory activity on DNA binding of NF-κB is due to cytotoxic effects.
Applied Sciences
Uncaria tomentosa (Willd. ex Schult.) DC. (Family: Rubiaceae), commonly known as cat’s claw, is a tropical medicinal vine originating at the Amazon rainforest and other areas of South and Central America. It has been traditionally used to treat asthma, abscesses, fever, urinary tract infections, viral infections, and wounds and found to be effective as an immune system rejuvenator, antioxidant, antimicrobial, and anti-inflammatory agent. U. tomentosa is rich in many phytoconstituents such as oxindole and indole alkaloids, glycosides, organic acids, proanthocyanidins, sterols, and triterpenes. Biological activities of U. tomentosa have been examined against various microorganisms and parasites, including pathogenic bacteria, viruses, and Plasmodium, Babesia and Theileria parasites. Several formulations of cat’s claw (e.g., tinctures, decoctions, capsules, extracts, and teas) are recently available in the market. The current review covers the chemical constituents, biological activiti...
Uncaria gambir (W. Hunter) Roxb: From phytochemical composition to pharmacological importance
Tropical Journal of Pharmaceutical Research, 2020
Purpose: To present an overview of the ethnopharmacology, phytochemistry, and pharmacological effects of the ‘wonder’ plant, Uncaria gambir (W. Hunter) Roxb.Methods: The literature search for information on phytochemical composition and pharmacological importance of U. gambir was undertaken using diverse electronic search engines, including Google, Scopus, Web of Science, scientific literature, and databases (Pubmed, Springer and Science Direct). Other relevant literature sources include books, book chapters, conference papers, theses, and other scientific publications.Results: Uncaria gambir Roxb possesses significant medicinal potentials as an antioxidant, anthelmintic, antibacterial, anti-diabetic, and for the management of osteoarthritis. Interest has increased among researchers for the utilization of this plant in complementary medicine, for example, to relieve sore throat, spongy gum, and dysentery, to treat atherosclerosis and obesity, and to prolong sexual intercourse.Conclu...
Alkaloids of uncaria elliptica
Phytochemistry, 1983
Six samples of Uncaria elliptica leaves from Thailand were investigated for their alkaloid content. Seven diastereoisomers of the pentacyclic heteroyohimbine series of alkaloids, 14+hydroxy-3-isorauniticine and tetrahydroalstonine N-oxide were isolated. Rauniticine oxindole A, rauniticine pseudoindoxyl, 3-isorauniticine pseudoindoxyl and akuammigine pseudoindoxyl were isolated for the first time as natural products. The roxburghine alkaloids, previously isolated from U. elliptica, were not detected and the species is more varied chemically than was hitherto supposed. The 'H NMR spectra of the eight diastereoisomeric pentacyclic heteroyohimbine alkaloids have been compared.
Constituents from the Stems of Malaysian Uncaria tomentosa
The Open Conference Proceedings Journal, 2014
Uncaria tomentosa (Willd. ex Schult.) DC. is well known as a medicinal plant that has been used for various treatments. This tropical vine grows up to 30 m tall and commonly found in natural forest. It has hook-like thorns that resemble the claws of a cat. The leaves are elliptic with a smooth edge, and grow in opposite whorls of two. Although there has not been any literature found on the availability of this species locally, we have discovered it in several parts of Peninsular Malaysia. A preliminary investigation of the stems of the plant has yielded three compounds, scopoletin, isopteropodine along with ß-sitosterol. The structures of the isolated compounds were characterized by analysis of spectral characteristics (mostly 1D, 2D NMR and mass spectrometry) and comparison with literature.
Food and Chemical Toxicology, 2014
Uncaria tomentosa have been used to treat viral diseases such as herpes due to multiple pharmacological effects, but its therapeutic efficacy against this virus have not been reported yet. Thus, in vitro antiherpetic activity of hydroethanolic extract from barks, purified fractions of quinovic acid glycosides and oxindole alkaloids was evaluated by plaque reduction assay, including mechanistic studies (virucidal, attachment and penetration action). Once exposure to physical agents might lead to reactivation of the herpetic infection, antimutagenic effect (pre-, simultaneous and post-treatment protocols) was also evaluated by Comet assay. The antiherpetic activity from the samples under investigation seemed to be associated with the presence of polyphenols or their synergistic effect with oxindole alkaloids or quinovic acid glycosides, once both purified fractions did not present activity when evaluated alone. Inhibition of viral attachment in the host cells was the main mechanism of antiviral activity. Although both purified fractions displayed the lowest antimutagenic activity in pre and simultaneous treatment, they provided a similar effect to that of cat's claw hydroethanolic extract in post-treatment. Given that purified fractions may result in a reduced antiherpetic activity, the use of cat's claw hydroethanolic extract from barks should be prioritized in order to obtain a synergistic effect.
Open Access Constituents from the Stems of Malaysian Uncaria tomentosa
2016
Abstract: Uncaria tomentosa (Willd. ex Schult.) DC. is well known as a medicinal plant that has been used for various treatments. This tropical vine grows up to 30 m tall and commonly found in natural forest. It has hook-like thorns that resemble the claws of a cat. The leaves are elliptic with a smooth edge, and grow in opposite whorls of two. Although there has not been any literature found on the availability of this species locally, we have discovered it in several parts of Peninsular Malaysia. A preliminary investigation of the stems of the plant has yielded three compounds, scopoletin, isopteropodine along with ß-sitosterol. The structures of the isolated compounds were characterized by analysis of spectral characteristics (mostly 1D, 2D NMR and mass spectrometry) and comparison with literature.
The Potency of the Genus Uncaria from East Borneo for Herbal Medicine Purposes: A Mini-review
Journal of Tropical Pharmacy and Chemistry
Uncaria is a genus of plants that are widely distributed in the tropics. There are about 5 of the 38 species of this genus growing in the tropical rain forests of East Borneo, Indonesia. For a long time, Uncaria is commonly used as a traditional medicine to treat various diseases by the Dayak tribe in Kalimantan, traditional people believe that Uncaria may be cured cancer, tumors, mioms, and cycts. Based on previous studies, the activity of the genus Uncaria has been widely reported such as cytotoxic, antimicrobial, antioxidant, antidiabetic, and thrombolytic activities. This article aims to summarize the potential of the Uncaria genus, focusing on 5 species from East Borneo, namely Uncaria nervosa, Uncaria longiflora, Uncaria gambir, Uncaria tomentosa and Uncaria cordata. The method used in this article is a literature study by collecting previous research articles related to the Uncaria genus. The results of the literature study show that the Uncaria genus in East Borneo has many ...
Phytochemical and Anti-Inflammatory of Uncaria gambir: A Review
Asian Journal of Pharmaceutical Research and Development, 2022
Inflammation occurs because of a response to tissue injury, cell death, cancer, ischemia, and degeneration. Uncaria gambir is one of the pharmacological solutions in overcoming inflammation. U. gambir has traditionally been used as a febrifuge, pain reliever, anti-inflammatory, antioxidant, and burn wound healing. The purpose of this paper is to present knowledge of the phytochemical and anti-inflammatory properties of U. gambir. This review provides literature evidence from 2011 to 2021. Three search sources were used as literature review sources (Pub Med, Science Direct, and Google Scholar). 13 articles in this review were based on our eligibility criteria. Pharmacological studies reported that U. gambir had been shown to have anti-inflammatory activity by reducing the volume of edema, inhibiting the enzymes COX-1, COX-2, 5-LOX, and iNOS. The phytochemical compounds contained in U. gambir were flavonoids, phenolics, polyphenols, catechins, spiroxylopropane rings, proanthocyanidins...