RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus (original) (raw)
In vitro and in vivo evidence that protein and U1 snRNP nuclear import in somatic cells differ in their requirement for GTP-hydrolysis, Ran/TC4 and RCC1 [published erratum appears in Nucleic Acids Res 1996 Jul 1;24(13):2626]
Herwig Ponstingl
Nucleic Acids Research, 1996
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The thermolability of nuclear protein import in tsBN2 cells is suppressed by microinjected Ran-GTP or Ran-GDP, but not by RanQ69L or RanT24N
Herwig Ponstingl
Journal of Cell Science, 1996
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A T42A Ran mutation: differential interactions with effectors and regulators, and defect in nuclear protein import
Alicia Villamarin
1997
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Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran
Anita Corbett
Journal of Molecular Biology, 1997
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Ran, a GTPase involved in nuclear processes: its regulators and effectors
Johanna Avis
Journal of Cell Science, 1996
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Separate Domains of the Ran GTPase Interact with Different Factors To Regulate Nuclear Protein Import and RNA Processing
Alicia Villamarin
Molecular and Cellular Biology, 1995
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Rna1p, a Ran/TC4 GTPase activating protein, is required for nuclear import
Anita Corbett
Journal of Cell Biology, 1995
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Engineered mutants in the switch II loop of ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import
Anita Corbett
Journal of Molecular Biology, 1999
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A GTPase Controlling Nuclear Trafficking: Running the Right Way or Walking RANdomly?
Pamela Silver
Cell, 1996
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The role of the ran GTPase in nuclear assembly and DNA replication: characterisation of the effects of Ran mutants
Johanna Avis
Journal of cell …, 1998
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Monoclonal Antibodies to NTF2 Inhibit Nuclear Protein Import by Preventing Nuclear Translocation of the GTPase Ran
Eze Paschal
2000
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Multiple pathways in nuclear transport: the import of U2 snRNP occurs by a novel kinetic pathway
Neil Michaud
Journal of Cell Biology, 1991
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Influence of cargo size on Ran and energy requirements for nuclear protein import
Janna Bednenko
Journal of Cell Biology, 2002
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Interactions between a nuclear transporter and a subset of nuclear pore complex proteins depend on Ran GTPase
Pamela Silver
Molecular and cellular biology, 1999
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Interaction between the small GTPase Ran/Gsp1p and Ntf2p is required for nuclear transport
Anita Corbett
Molecular and cellular biology, 1997
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Nuclear Import of the Ran Exchange Factor, RCC1, Is Mediated by at Least Two Distinct Mechanisms
Michael Nemergut
The Journal of Cell Biology, 2000
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A cytoplasmically anchored nuclear protein interferes specifically with the import of nuclear proteins but not U1 snRNA
Utz Fischer
The Journal of cell biology, 1993
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Interaction of the Nuclear GTP-Binding Protein Ran with Its Regulatory Proteins RCC1 and RanGAP1
Herwig Ponstingl
Biochemistry, 1995
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Nucleocytoplasmic trafficking of proteins: With or without Ran?
Ursula Stochaj
BioEssays, 1999
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Conformational States of the Nuclear GTP-Binding Protein Ran and Its Complexes with the Exchange Factor RCC1 and the Effector Protein RanBP1 †
Jörg Becker
Biochemistry, 1999
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Structural biology and regulation of protein import into the nucleus
Gergely Róna
Journal of molecular biology, 2015
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Stress-mediated inhibition of the classical nuclear protein import pathway and nuclear accumulation of the small GTPase Gsp1p
Ursula Stochaj
The FASEB Journal, 2000
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An ATP-dependent, Ran-independent Mechanism for Nuclear Import of the U1A and U2B'' Spliceosome Proteins
Iain Mattaj
The Journal of Cell Biology, 2000
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The Cytoplasmic Filaments of the Nuclear pore Complex are Dispensable for Selective Nuclear Protein Import
Martin Goldberg
Journal of Cell Biology, 2002
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The mechanism of inhibition of Ran-dependent nuclear transport by cellular ATP depletion
Thai Ho
The Journal of cell biology, 2002
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The role of Ran in nuclear function
Mary Dasso
Current Opinion in Cell Biology, 2000
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The balance of RanBP1 and RCC1 is critical for nuclear assembly and nuclear transport
Mary Dasso
Molecular biology of the cell, 1997
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RanBP3 contains an unusual nuclear localization signal that is imported preferentially by importin-alpha3
Matthias Köhler
Molecular and cellular biology, 1999
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Dynamic localization of the nuclear import receptor and its interactions with transport factors
Anita Corbett
The Journal of Cell Biology, 1996
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Nuclear Protein Import: Ran--GTP Dissociates the Karyopherin alpha beta Heterodimer by Displacing alpha from an Overlapping Binding Site on beta
Aurelian Radu
Proceedings of The National Academy of Sciences, 1996
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Two separate regions essential for nuclear import of the hnRNP D nucleocytoplasmic shuttling sequence
michiyuki yamada
The FEBS Journal, 2005
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