m7GTP S is a strong and stable inhibitor of cap-dependent translation (original) (raw)

Nucleic Acids Symposium Series, 2008

Abstract

Two diastereomers of 7-methylguanosine 5'-O-(1-thiotriphosphate) have been synthesized and resolved by RP HPLC. Preliminary studies revealed that these new analogs of mRNA cap are characterized by high affinity for eIF4E, resistance towards DcpS pyrophosphatase and high potency to inhibit cap-dependent translation.

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