Diterpenes and phenolic compounds from Sideritis pullulans (original) (raw)

Phytochemical investigation of Sideritis pullulans aerial part and root extracts allowed to isolate six entkaurane diterpenes, two phenylpropanoids, and one coumarin, identified as 1a,3a,7b,18-tetrahydroxyent-kaur-16-ene (sideripullol A) (1), 3a,11a,18-trihydroxy-ent-kaur-16-ene (sideripullol B) (2), 3a, 7b,18-trihydroxy-17-nor-ent-kauran-16-one (sideritone A) (3), 3a,7b-dihydroxy-18-acetyloxy-17-norent-kauran-16-one (sideritone B) (4), 3a,7b,16a,17-tetrahydroxy-18-acetyloxy-ent-kaurane (sideripullol C) (5), 7b,16a,17,18-tetrahydroxy-ent-kaurane (sideripullol D) , and 7-demethyl-8-methoxycoumarsabin (9), respectively. Twenty known compounds, including phenolics, flavonol glycosides, iridoids, diterpenes, sesquiterpenes, lignans, coumarins, and phenylpropanoids were also isolated and characterized. All diterpenes were evaluated for their cytotoxic activity. (A. Braca).