Ganglioneurocytoma of the spinal cord: report of a case and review of literature (original) (raw)
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Ganglioneurocytoma: Distinctive variant of central neurocytoma
Pathology International, 2007
throughout the tumor. The tumor cell nuclei were positive for NeuN. Fine granular positivity for synaptophysin was seen in the cytoplasm of the tumor cells, and background fibrils and the cytoplasm of some ganglioid cells were positive for neurofilament. Several cases of central neurocytoma with ganglioid cells have been reported, with some diagnosed as ganglioneurocytoma. However, histopathological details and persuasive figures have been lacking. It is considered that the diagnosis of ganglioneurocytoma should be applied to tumors displaying the following characteristics: (i) clinical aspects such as location, demarcation and growth rate consistent with neurocytoma; (ii) transition between neurocytoma cells and ganglion cells; and (iii) ganglioid cells distributed throughout the tumors.
Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult. Case report
PINAL neuroblastoma is an extremely rare tumor in adults, with only four cases reported in the literature. The prognosis for patients with this tumor has been uniformly poor, with no long-term survival previously reported. We describe a case of spinal neuroblastoma in a 32-year-old woman who had presented with a history of retroperitoneal ganglioneuroma 11 years earlier. The patient has survived 10 more years with relatively stable disease and the recent development of metastases. To our knowledge, this is the first report of malignant transformation of ganglioneuroma into neuroblastoma.
Ganglioneuroblastoma of the spinal cord
AJNR. American journal of neuroradiology, 1995
We report a case of ganglioneuroblastoma of the spinal cord in a 42-year-old man. MR examination was nonspecific, and the diagnosis was made from histologic findings. The MR picture was that of an intramedullary, mainly solid tumor with a central necrotic or cystic portion. The clinical picture and course were also nonspecific.
Acta Neuropathologica, 1994
We report a case of spinal cord neurocytoma in a 67-year-old man who had experienced a progressive numbness of the left foot during the previous 4 years. Magnetic resonance imaging showed a well-defined intramedullary tumor located at the T10-Tll level. The pathological examination revealed histological characteristics described in neurocytomas. The tumor cells showed a uniform small nucleus and clear or slightly eosinophilic cytoplasm with frequent perinuclear halos, resembling the picture of oligodendroglioma. Some tumor cells exhibited mature ganglion cell appearance. Electron microscopy showed cells with microtubules and dense-core vesicles in their cytoplasm and cytoplasmic process. Immunohistochemically, the majority of tumor cells expressed synaptophysin and neuronspecific enolase. We conclude that this tumor is an exceptional case of neurocytoma located in the spinal cord, and consider that the term neurocytoma can be applied to tumors with neuronal differentiation intermediate between neuroblastoma and ganglioneuroma, even if arising in CNS outside of the intracranial ventricular system. Key words Neurocytoma 9 Spinal cord differentiation. It was first described by Hassoun et al. . Since then about 100 other cases have been reported ], very few of which were shown to be located in parts of the brain other than in the ventricular system . Only four cases have been described in the cervical cord . In this report we present a spinal cord tumor in a 67-year-old man, with the histological, immunohistochemical and ultrastructural characteristics of a central neurocytoma.
Neurocytoma of the spinal cord: report of three cases and review of the literature
Acta Neurochirurgica, 2009
The spinal cord is a very rare location for extraventricular neurocytomas. Composed of small round cells with neuronal differentiation, neurocytoma has a particularly favourable prognosis. Long disease-free intervals have been observed in patients who received sub-total removal and radiotherapy. A careful intra-operative frozen section examination is helpful in avoiding excessive surgical tissue disturbance and to identify the best treatment option. To date, eight cases of neurocytoma of the spinal cord have been described. We report three more patients; one with very long survival, and review the published literature for this condition.
Ganglioneuroblastoma of the thoracic spinal cord: a very rare case report
Acta medica (Hradec Králové) / Universitas Carolina, Facultas Medica Hradec Králové, 2012
An eight-month-old male child was admitted with weakness and swelling in the feet. Paraparesis and bilateral lower extremity edema were present in the neurological examination. Thoracic MRI showed an intradural intramedullary mass 61 x 11 mm in size in the T5-T10 levels. Laminotomy between the T5-T10 vertebrae was performed. A mass with smooth borders was separated from most of the neural tissue. In the postoperative MRI, we observed a contrast enhancing area, considered a residual fragment, only 5 x 4 mm in size. Histopathological properties were compatible with the intermixed subtype of ganglioneuroblastoma. Only a limited number of thoracic cord Ganglioneuroblastoma reports have been previously published. Although very rare in children and young adults, ganglioneuroblastoma should be included in the differential diagnosis of thoracic cord tumors. It is difficult to obtain a preoperative diagnosis with clinical features and radiological investigations. Diagnosis depends on histopa...
Primary extradural spinal ganglioneuroblastoma : a case report
Turkish Neurosurgery, 2012
We report a case of ganglioneuroblastoma of the spinal cord in a 25-year-old man. Clinical history was short with paraparesis and bladder involvement. The MRI picture was that of an extradural solid tumor with extension to both intervertebral foramina, more suggestive of nerve sheath tumour rather than malignant embryonal tumour. Diagnosis was established by histopathological study. We could not find such a presentation of spinal ganglioneuroblastoma as an extradural, primary tumour in the literature. We discuss the radio-pathological features, surgical management and post-operative outcome.
Primary intraspinal ganglioneuroblastoma of the thoracic spine: A rare case report
Indian Journal of Pathology and Microbiology, 2012
I n d I a n J o u r n a l o f P a t h o l o g y a n d M I c r o b I o l o g y -5 5 ( 4 ) , o c t o b e r -d e c e M b e r 2 0 1 2 535 Case Report ABSTRACT Cerebral ganglioneuroblastoma is an embryonal tumor of the central nervous system, which has been rarely encountered into the spinal cord. The standard treatment for ganglioneuroblastoma is complete surgical excision. A 15-year old boy was presented with cord compression. Magnetic resonance imaging revealed an intradural and intramedullar enhancing lesion over T2 spine. A histomorphological diagnosis was made in the presence of immature small round cells admixed with a good number of ganglion cells. The morphological diagnosis was verified by immunohistochemistry. This is the first reported case of compressive myelopathy in the thoracic region of the spine.
Central neurocytoma: report of two cases
Arquivos de Neuro-Psiquiatria, 2005
INTRODUCTION: Central neurocytomas are rare neuroectodermal tumors believed to arise from the subependymal matrix of the lateral ventricles. CASE REPORTS: A 26-year-old woman and a 33-year-old man each had a large, heterogeneous, contrast enhancing mass in the lateral ventricles at the foramen of Monro causing bilateral hydrocephalus. The woman died after surgery, but the man is asymptomatic after three years. HISTOPATHOLOGY: Both tumors were composed of isomorphic rounded cells positive for synaptophysin, chromogranin and NSE, while some reacted for GFAP, vimentin and S-100 protein. Electron microscopy revealed neuropil-like tissue between cells, but synapses were rare.