NF-kB activation and overexpression of regulated genes in human diabetic nephropathy (original) (raw)

Abstract

Background. Nuclear factor-kB (NF-kB) regulates genes involved in renal disease progression, such as the chemokines monocyte chemoattractant protein-1 (MCP-1) and RANTES. NF-kB is activated in experimental models of renal injury, and in vitro studies also suggest that proteinuria and angiotensin II could be important NF-kB activators. It has been proposed that locally produced MCP-1 may be involved in the development

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