Differential Dopaminergic Modulation of Neostriatal Synaptic Connections of Striatopallidal Axon Collaterals (original) (raw)

2009, Journal of Neuroscience

Nicola, Saleem M. and Robert C. Malenka. Modulation of synulants . In contrast, the dorsal aptic transmission by dopamine and norepinephrine in ventral but striatum is required for the execution of planned motor behavnot dorsal striatum. J. Neurophysiol. 79: 1768-1776, 1998. Alior (Graybiel et al. 1994 and is implicated in the pathophysithough the ventral striatum (nucleus accumbens; NAc) and dorsal ology of Parkinson's disease and Huntington's chorea. Both striatum are associated with different behaviors, these structures nuclei may be involved in psychiatric diseases such as schizoare anatomically and physiologically similar. In particular, dopaphrenia (Swerdlow and Koob 1987). minergic afferents from the midbrain appear to be essential for the One element that is common to almost all hypotheses that normal functioning of both nuclei. Although a number of studies attempt to explain the behavioral functions of the NAc and have examined the effects of dopamine on the physiology of NAc or striatal cells, results have varied, and few studies have compared striatum is the paramount importance of the midbrain dopadirectly the actions of dopamine on both of these nuclei. Here we minergic projection. Despite convincing behavioral evidence use slice preparations of the NAc and dorsal striatum to compare of the importance of dopamine (DA), however, little is how synaptic transmission in these nuclei is modulated by catecholknown about the physiological actions of DA on neurons in amines. As previously reported, dopamine depressed excitatory these structures. Recently, we and others have shown that postsynaptic potentials (EPSPs) and inhibitory postsynaptic potenin the NAc, DA presynaptically depresses both excitatory tials (IPSPs) in the NAc. Surprisingly, however, neither EPSPs nor (Harvey and Lacey 1996; Nicola et al. 1996; Pennartz et al. IPSPs in the dorsal striatum were affected by dopamine. Similarly, 1992) and inhibitory (Nicola and Malenka 1997) synaptic norepinephrine depressed excitatory synaptic transmission in the transmission by activation of a D1-like DA receptor. Similar

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