Conformational Changes of the Insulin Receptor upon Insulin Binding and Activation As Monitored by Fluorescence Spectroscopy † (original) (raw)

Conformational states of the insulin receptor

Esther Schenker

Biochemical and Biophysical Research Communications, 1988

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Oligomeric states of the insulin receptor: binding and autophosphorylation properties

Joanna Kubar

Biochemistry, 1989

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Thermodynamics of the interaction of insulin with its receptor

Magali Waelbroeck

Journal of Biological Chemistry

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Demonstration that the insulin receptor undergoes an early structural modification following insulin binding

Peter Sonksen

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1986

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Insulin binding monitored by fluorescence correlation spectroscopy

Rudolf Rigler

Diabetologia, 2001

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Basal autophosphorylation of insulin receptor occurs preferentially on the receptor conformation exhibiting high affinity for insulin and stabilizes this conformation

Joanna Kubar

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Evidence concerning the mechanism of insulin-receptor interaction and the structure of the insulin receptor from biological properties of covalently linked insulin …

Richard Jones

Biochemical …, 1983

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Glucose binds to the insulin receptor affecting the mutual affinity of insulin and its receptor

Robert Root-Bernstein

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Toward the Active Conformation of Insulin

Michael Weiss

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Dynamics of the interaction between the insulin receptor and protein tyrosine-phosphatase 1B in living cells

Tarik Issad

EMBO Reports, 2003

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Structural insights into ligand-induced activation of the insulin receptor

George Lovrecz

Acta Physiologica, 2007

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Evidence for an early degradative event to the insulin molecule following binding to hepatocyte receptors

Peter Sonksen

Biochimica et Biophysica Acta (BBA) - Biomembranes, 1986

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Structure and dynamics of the insulin receptor: implications for receptor activation and drug discovery

Judith Klein-seetharaman, Piraveen Piv Gopalasingam

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Spectroscopic and molecular dynamics simulation studies of the interaction of insulin with glucose

Roberto Purrello, Antonio Raudino

International Journal of Biological Macromolecules, 2001

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High-Affinity Insulin Binding: Insulin Interacts with Two Receptor Ligand Binding Sites

Linda Whittaker

Biochemistry, 2008

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Insulin binding to rat liver membranes predicts a homogeneous class of binding sites in different affinity states that may be related to a regulator of insulin binding

Erik Helmerhorst

Biochemistry, 1993

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Recycling of photoaffinity-labeled insulin receptors in rat adipocytes: Dissociation of insulin-receptor complexes is not required for receptor recycling

Kim Heidenreich

Journal of Biological Chemistry

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Functional labeling of insulin receptor subunits in live cells

Robert Ballotti

Journal of Biological Chemistry, 1989

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Comparative 2D NMR studies of human insulin and despentapeptide insulin: sequential resonance assignment and implications for protein dynamics and receptor …

Michael Weiss

Biochemistry, 1991

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The insulin-receptor interaction: Is the kinetic approach for inferring negative-cooperative site-site interactions valid?

Erik Helmerhorst

Biochemical and Biophysical Research Communications, 1987

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Receptor binding redefined by a structural switch in a mutant human insulin

Michael Weiss

1991

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Characterization of a second ligand binding site of the insulin receptor

Linda Whittaker

Biochemical and Biophysical Research Communications, 2006

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Solution structure of an ultra-stable single-chain insulin analog connects protein dynamics to a novel mechanism of receptor binding

Nalinda Wickramasinghe

The Journal of biological chemistry, 2017

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The Structure of a Mutant Insulin Uncouples Receptor Binding from Protein Allostery: AN ELECTROSTATIC BLOCK TO THE TR TRANSITION

Jonathan Whittaker

Journal of Biological Chemistry, 2008

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Characterization of the Functional Insulin Binding Epitopes of the Full-length Insulin Receptor

Jonathan Whittaker

Journal of Biological Chemistry, 2005

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Increased affinity of insulin for its receptor following conjugation to a second protein

Mario Ariatti

Medical Hypotheses, 1991

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How insulin engages its primary binding site on the insulin receptor

Jonathan Whittaker

Nature, 2013

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Interaction of the Insulin Receptor with the Receptor-Like Protein Tyrosine Phosphatases PTP and PTP in Living Cells

Tarik Issad

Molecular Pharmacology, 2005

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Toward the Active Conformation of Insulin: STEREOSPECIFIC MODULATION OF A STRUCTURAL SWITCH IN THE B CHAIN

Michael Weiss

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The reversible and irreversible autophosphorylations of insulin receptor kinase

Lawrence Argetsinger

Journal of Biological Chemistry, 1992

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Intermolecular transphosphorylation between insulin receptors and EGF-insulin receptor chimerae

J. Schlessinger

Cell Biology International Reports, 1990

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