Analysis of TLR2, TLR4, TLR5, and TLR9 Polymorphisms in Chronic Rhinosinusitis (CRS) (original) (raw)

The study investigates polymorphisms in TLR2, TLR4, TLR5, and TLR9 genes in patients with Chronic Rhinosinusitis (CRS) to determine their association with the disease. A significant association was found between the TLR2 Arg 753 Stop variant and CRS susceptibility, particularly in patients without nasal polyps, suggesting a potential role of this variant in modulating immune response and susceptibility to infections relevant to CRS. Further research is indicated to elucidate the mechanisms by which these polymorphisms contribute to CRS.