FORMULATION AND EVALUATION OF TRANSDERMAL GEL OF LORNOXICAM AND COMPARITIVE DIFFUSION STUDY BY IONTOPHORESIS AND CHEMICAL ENHANCERS (original) (raw)

Transdermal delivery of drugs through the skin to systemic circulation provides a convenient route of administration for a variety of clinical indications. The purpose of present investigation was to develop Lornoxicam transdermal gel and its iontophoretic delivery to enhance its permeation for systemic effect and to avoid side effects and minimize frequency of administration. Lornoxicam (NSAIDs) is a COX-1 and COX-2 inhibitor used in the treatment of inflammation, pain and edema, rheumatoid arthritis and so on. Transdermal gel of Lornoxicam was formulated using triethanolamine (5%) as solvent, carbopol 934p as gelling polymer and various penetration enhancers and enhancement in its permeation by using chemical enhancers and iontophoresis was investigated. Formulated gel was evaluated with respect to different physiochemical parameters such as pH, viscosity, spreadability, gel strength. Permeation study was carried out using cellophane membrane and phosphate buffer pH 6.8 for 6 hours. Anti-inflammatory activity of Lornoxicam gel was studied in albino rats by carrageenan induced paw edema method in which Lornoxicam gel was delivered through rat’s skin by passive delivery and iontophoretic delivery. Iontophoresis for 10 minutes was carried out in combination with penetration enhancers as well as without penetration enhancers. Iontophoretic delivery of optimized formulation (F3) which has chemical penetration enhancers (2% tween 80) showed higher anti-inflammatory activity (73%) as compared to passive delivery of F1 (22%) and in chemical method of delivery of F3 (40%) in 1 to 4 hours. So, delivery of Lornoxicam is affected by various methods of permeation enhancement in which combination of physical and chemical methods seems to be much effective. Physiochemiclly stable and non-irritant Lornoxicam gel was formulated which could deliver significant amount of active substances across the skin in-vitro and in-vivo which elicit the anti-inflammatory activity.