Regulation of Synaptic Vesicle Recycling by Calcium and Serotonin (original) (raw)

recent study of protein kinase C activators on bovine Berkeley, California 94720 chromaffin cell secretion suggests that exocytosis is enhanced by an increase in the pool of vesicles available for release (Gillis et al., 1996). Phorbol esters increased Summary the initial rapid phase of secretion evoked by Ca 2ϩ released by photolysis of caged Ca 2ϩ , the early plateau Serotonin, a neuromodulator at the crayfish neuroincrease in capacitance to prolonged depolarization, muscular junction, regulates neurotransmission withand the average size of paired responses without alterout changing intracellular calcium levels. However, the ing the depression expressed by the ratio of the two mechanism of this regulation remains unclear. By responses. All of these results suggest an increase in analysis of synaptic depression using a depletion the number of docked and primed vesicles available for model and measurement of vesicle recycling using the release.