Granulosa Cell Tumors of the Equine Ovary (original) (raw)
Related papers
Granulosa cell tumour in two speyed bitches
Australian Veterinary Journal, 2001
Granulosa cell tumours are uncommon ovarian tumours in the bitch and are rare in speyed bitches. This case report describes two cases of granulosa cell tumour in bitches that were speyed at less than 1-year-of-age. Both animals presented with persistent vulval bleeding. Although the majority of granulosa cell tumours are large enough to be palpated by the time of presentation, both tumours were relatively small. Granulosa cell tumour is a possible complication of incomplete ovarian excision at the time of ovariohysterectomy. In cases of granulosa cell tumour in previously speyed bitches, with no evidence of metastases, tumour resection should be curative. Ovaries should be double-checked at the initial ovariohysterectomy to ensure all normal ovarian tissue has been excised.
Dysgerminoma and granulosa cell tumor in a bitch
Dysgerminoma and granulosa cell tumor are neoplasms of the ovary of domestic animals, originating from germ cells and sex-cords cells, respectively. These neoplasms generally occur unilaterally, and usually as a single neoplasm. This report describes a case of a dysgerminoma in the right ovary and a granulosa cell tumor in the left ovary in a six years old bitch. An Akita and Siberian Husky crossbred bitch was admitted at the Veterinary Hospital (Universidade Vila Velha), with a history of purulent vaginal discharge, irregular estrous cycle, fatigue, polydipsia and polyuria. Ultrasound exam demonstrated bilateral ovarian neoplasms, and the animal was subjected to ovariohysterectomy. Macroscopic and microscopic features found in right and left ovaries were typical of dysgerminoma and granulosa cells tumor Sertoli-like, respectively. The uterus had cystic endometrial hyperplasia associated with mild metritis. Ovarian neoplasms occurring bilaterally are uncommon especially with different cell origins and distinct histopathological patterns in each ovary as described in this report.
Mesenteric metastasis of granulosa cell tumor in a bitch – a case report
Revista Colombiana de Ciencias Pecuarias, 2020
Anamnesis: A 5-year-old mixed breed entire bitch was presented with bloody vaginal discharge and abdominal distension. Clinical and laboratory findings: Physical examination and abdominal ultrasonography suggested the presence of a left ovarian tumor. At histopathological examination it was diagnosed as granulosa cell tumor. Treatment approach: An exploratory laparotomy was performed followed by ovariohysterectomy to remove the intra-abdominal mass. Conclusion: The clinical, ultrasonographic and histologic signs in this case support other literature reports. Ultrasonography, in combination with histopathologic analysis is a fundamental tool for detection of ovarian tumors, especially tumors of the granulosa cells.
Surgical removal of a granulosa cell tumor from a heifer
The Canadian veterinary journal. La revue vétérinaire canadienne, 1984
A twelve month old, noncycling Holstein-Friesian heifer, was examined because of abnormal udder development. Rectal palpation revealed a tense right uterine horn. A solid mass in the right abdomen was detected by ballottement. A granulosa cell tumor of the right ovary was removed and nine months later the animal conceived.
Granulosa cell tumour in a female dromedary camel
Comparative Clinical Pathology, 2013
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Ovarian tumours in Arabian mares
Comparative Clinical Pathology, 2014
Of 222 infertile Arabian mares, unilateral ovarian enlargement was detected in three cases. Ultrasonography suggested the presence of ovarian tumours. Blood samples were taken for hormonal analysis, and the mares underwent surgery for ovarian exploration. Ovarian specimens were processed for microscopic examination. On histopathology, an adult-type granulosa cell tumour (GCT), a mixed germ cell tumour and a lowgrade Sertoli cell tumour were diagnosed. The GCT (6.5 cm in diameter) was rounded and cystic, with a central hypoechogenic area. The ovarian tissue was entirely replaced by polygonal neoplastic cells. The mixed germ cell tumour (15.3 cm in diameter) was hard and non-homogeneous. The ovary contained insular patterns of round, oval or spindle cells with myxomatous and hyalinised stroma. The stroma also contained osteoid tissue. The ovarian low-grade Sertoli cell tumour (19×20 cm) was a solid, fairly round homogeneously echogenic structure. The ovarian tissue was completely replaced by aggregated tubules lined by Sertoli-type cells surrounded by abundant fibrous stroma. The three types of tumours secreted relatively low levels of estradiol 17β and progesterone, whereas the level of inhibin-B was extremely high in the case of the Sertoli cell tumour. In conclusion, this study described three types of ovarian tumours causing infertility in Arabian mares. Furthermore, the Sertoli cell tumour is described here for the first time in mares.
Malignant Ovarian Granulosa Cell Tumour in a Ewe
Acta Veterinaria Brno, 2009
We describe a rare case of malignant granulosa cell tumour in an adult ewe, euthanised due to progressive weight loss. Necropsy examination revealed a neoplastic enlargement of the right ovary, multifocal neoplastic masses in the lung and spleen, and severe enlargement of mediastinal and iliacal lymph nodes. Histopathology of the right ovary revealed a malignant ovarian granulosa cell tumour with metastases to the lung, spleen, and mediastinal and iliacal lymph nodes. Immunohistochemistry confirmed histopathological diagnosis. Neoplastic cells reacted positively for CK MNF 116 and vimentin and were negative for CK 7 and desmin. To our knowledge this is the first report of a malignant granulosa cell tumour in ewe.
2014
Of 222 infertile Arabian mares, unilateral ovarian enlargement was detected in three cases. Ultrasonography suggested the presence of ovarian tumours. Blood samples were taken for hormonal analysis, and the mares underwent surgery for ovarian exploration. Ovarian specimens were processed for microscopic examination. On histopathology, an adult-type granulosa cell tumour (GCT), a mixed germ cell tumour and a lowgrade Sertoli cell tumour were diagnosed. The GCT (6.5 cm in diameter) was rounded and cystic, with a central hypoechogenic area. The ovarian tissue was entirely replaced by polygonal neoplastic cells. The mixed germ cell tumour (15.3 cm in diameter) was hard and non-homogeneous. The ovary contained insular patterns of round, oval or spindle cells with myxomatous and hyalinised stroma. The stroma also contained osteoid tissue. The ovarian low-grade Sertoli cell tumour (19×20 cm) was a solid, fairly round homogeneously echogenic structure. The ovarian tissue was completely replaced by aggregated tubules lined by Sertoli-type cells surrounded by abundant fibrous stroma. The three types of tumours secreted relatively low levels of estradiol 17β and progesterone, whereas the level of inhibin-B was extremely high in the case of the Sertoli cell tumour. In conclusion, this study described three types of ovarian tumours causing infertility in Arabian mares. Furthermore, the Sertoli cell tumour is described here for the first time in mares.
Vaginal prolapse related to ovarian granulosa cell tumor in an Anatolian Shepherd
Turkish Journal of Veterinary & Animal Sciences
A 4-year old, primiparous, female Anatolian Shepherd dog was presented for evaluation of type II vaginal prolapse with alopecia of the left perineal skin. Hematological analyses demonstrated leukocytosis and thrombocytopenia. Estradiol (E2) and progesterone (P4) levels were 156 pg/mL and 2.3 ng/mL, respectively. Th e vaginal smear was predominantly (at least 80%) made up of anuclear superfi cial cells. An abdominal ultrasonography revealed a heterogeneous multicystic mass with anechoic areas adjacent to the caudal pole of the left kidney. An ovariohysterectomy was performed. Ten days aft er the surgery, the prolapsed vagina was completely regressed. A histopathological examination of the ovarian mass demonstrated that it was a granulosa cell tumor.
Ovarian Tumor in a Mare—Thecoma—Case Report
Journal of Equine Veterinary Science, 2013
Thecomas are tumors originating from the ovarian stroma and of rare occurrence in the equine species. Clinical, ultrasonographic, endocrine, and histopathologic descriptions of thecoma are scarce. This article aims to describe a case of ovarian changes in a mare with anomalous growth of the right ovary and anestrus for 1 year. After surgical removal, the ovarian growth was diagnosed as a thecoma. Histopathological findings were consistent with the findings previously described in the literature, characteristic of a thecoma, and decisive for the correct diagnosis.