Synthesis and characterization of 1,3-dihydro-benzo[A][1,4]diazepin-2-one derivatives: Part 3. New potent non-competitive metabotropic glutamate receptor 2/3 antagonists
Geo Adam
Bioorganic Medicinal Chemistry Letters, 2008
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New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Robert Lutjens
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Synthesis and characterization of 1,3-dihydro-benzo[b][1,4]diazepin-2-one derivatives: Part 4. In vivo active potent and selective non-competitive metabotropic glutamate receptor 2/3 antagonists
Vincent Mutel, Silvia Gatti
Bioorganic & Medicinal Chemistry Letters, 2010
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Piperidyl amides as novel, potent and orally active mGlu5 receptor antagonists with anxiolytic-like activity
Thomas Troxler, Ralf Glatthar
Bioorganic & Medicinal Chemistry Letters, 2010
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Increased Potency and Selectivity for Group III Metabotropic Glutamate Receptor Agonists Binding at Dual sites
Jean-philippe Pin
Journal of medicinal chemistry, 2018
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Structure−Activity Relationships Comparing N-(6-Methylpyridin-yl)-Substituted Aryl Amides to 2-Methyl-6-(substituted-arylethynyl)pyridines or 2-Methyl-4-(substituted-arylethynyl)thiazoles as Novel Metabotropic Glutamate Receptor Subtype 5 Antagonists
Alice Rodriguez
Journal of Medicinal Chemistry, 2009
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Synthesis, molecular modeling and preliminary biological evaluation of 1-amino-3-phosphono-3-cyclopentene-1-carboxylic acid and 1-amino-3-phosphono-2-cyclopentene-1-carboxylic acid, two novel agonists of metabotropic glutamate receptors of group III
Rainer Kuhn
Bioorganic & Medicinal Chemistry Letters, 2000
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Synthesis and metabotropic glutamate receptor antagonist activity of N1-substituted analogs of 2R,4R-4-aminopyrrolidine-2,4-dicarboxylic acid
Matthew Valli
Bioorganic & Medicinal Chemistry Letters, 1998
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Metabotropic glutamate 2/3 receptors as drug targets
Gerard Marek
Current Opinion in Pharmacology, 2004
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LY341495 is a nanomolar potent and selective antagonist of group II metabotropic glutamate receptors
Paul Ornstein
Neuropharmacology, 1998
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LY354740 is a Potent and Highly Selective Group II Metabotropic Glutamate Receptor Agonist in Cells Expressing Human Glutamate Receptors
James Monn
Neuropharmacology, 1997
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1,3,5-Trisubstituted Pyrazoles as Potent Negative Allosteric Modulators of the mGlu2/3 Receptors
Fabrice Jourdan
ChemMedChem, 2017
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Synthesis, SAR and Unanticipated Pharmacological Profiles of Analogues of the mGluR5 Ago-potentiator ADX-47273
Alice Rodriguez
ChemMedChem, 2009
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Discovery of a potent and brain penetrant mGluR5 positive allosteric modulator
Christoffer Bundgaard
Bioorganic & Medicinal Chemistry Letters, 2009
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(2S,4S)-2-Amino-4-(2,2-diphenylethyl)pentanedioic acid selective group 2 metabotropic glutamate receptor antagonist
Belen Yruretagoyena
Bioorganic & Medicinal Chemistry Letters, 1998
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Discovery of 1,4-Disubstituted 3-Cyano-2-pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
Robert Lutjens
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Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors
P. Conn
Current Opinion in Pharmacology, 2006
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Evidence for the Role of Metabotropic Glutamate (mGlu)2 Not mGlu3 Receptors in the Preclinical Antipsychotic Pharmacology of the mGlu2/3 Receptor Agonist (-)-(1R,4S,5S,6S)-4-Amino-2-sulfonylbicyclo[3.1.0]hexane-4,6-dicarboxylic Acid (LY404039)
Kjell Svensson
Journal of Pharmacology and Experimental Therapeutics, 2008
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Methyl Substitution of 2-Aminobicyclo[3.1.0]hexane 2,6-Dicarboxylate (LY354740) Determines Functional Activity at Metabotropic Glutamate Receptors: Identification of a Subtype Selective mGlu2 Receptor Agonist
James Monn
Journal of Medicinal Chemistry, 2005
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Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist
James Monn
Naunyn-Schmiedeberg's Archives of Pharmacology, 1998
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Discovery of 1‑Butyl-3-chloro-4-(4-phenyl-1-piperidinyl)- (1H)‑pyridone (JNJ-40411813): A Novel Positive Allosteric Modulator of the Metabotropic Glutamate 2 Receptor
Robert Lutjens
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Pharmacological characterization of 1-aminoindan-1,5-dicarboxylic acid, a potent mGluR1 antagonist
Flavio Moroni
The Journal of pharmacology and experimental therapeutics, 1997
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Metabotropic Glutamate Receptor Ligands as Novel Therapeutic Agents
Ashley Brady
The Receptors, 2008
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Metabotropic glutamate receptors as drug targets: what's new?
R. Ngomba, Roberto Gradini
Current Opinion in Pharmacology, 2015
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SIB-1757 and SIB-1893: selective, noncompetitive antagonists of metabotropic glutamate receptor type 5
Edwin Johnson
The Journal of pharmacology and experimental therapeutics, 1999
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Pharmacological Characterization of a New, Orally Active and Potent Allosteric Metabotropic Glutamate Receptor 1 Antagonist, 4-[1-(2-Fluoropyridin-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide (FTIDC)
奈穂子 金子
Journal of Pharmacology and Experimental Therapeutics, 2007
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Discovery of novel positive allosteric modulators of the metabotropic glutamate receptor 5 (mGlu5)
Scott Throner
Bioorganic & Medicinal Chemistry Letters, 2011
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New 4-Functionalized Glutamate Analogues Are Selective Agonists at Metabotropic Glutamate Receptor Subtype 2 or Selective Agonists at Metabotropic Glutamate Receptor Group III
Thierry Gefflaut
Journal of Medicinal Chemistry, 2016
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2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist
Peter Flor
Neuropharmacology, 1999
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A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure–activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1 H-pyrrole-2-carboxylic acid, LY2059346
Esteban Dominguez
Bioorganic & Medicinal Chemistry Letters, 2006
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BAY36-7620: a potent non-competitive mGlu1 receptor antagonist with inverse agonist activity
Laurent Prézeau
Molecular …, 2001
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