DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos (original) (raw)

Methylation of DNA is crucial for cell differentiation and stability in mammals, but it must be erased for germline development and early embryo formation. This review discusses advances in understanding DNA methylation dynamics during epigenetic reprogramming in germline and preimplantation embryos, highlighting new insights gained from next-generation sequencing and enzymatic pathways for DNA demethylation. The processes involved are complex and involve the establishment and removal of epigenetic signatures, which are pivotal for successful sexual reproduction and embryonic development.