Vertebrate Smoothened functions at the primary cilium (original) (raw)

AI-generated Abstract

The Hedgehog (Hh) pathway is crucial for vertebrate development, with Smoothened (Smo) being a key player in signal transduction. This study demonstrates that Smo localizes to the primary cilium, a process regulated by Hh pathway activity. The identified ciliary localization motif in Smo is essential for its function; mutations in this motif disrupt Smo localization and activity in both cell culture and zebrafish models. These findings suggest that Smo's activity is intrinsically linked to its localization at the primary cilium, underscoring the cilium's role in signal transduction.

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