Superior human leukocyte reconstitution and susceptibility to vaginal HIV transmission in humanized NOD scid IL2Rγ −/− (NSG) BLT mice (original) (raw)

Virology, 2011

Abstract

Humanized Bone marrow/Liver/Thymus (BLT) mice recapitulate the mucosal transmission of HIV, permitting study of early events in HIV pathogenesis and evaluation of preexposure prophylaxis methods to inhibit HIV transmission. Human hematopoiesis is reconstituted in NOD-scid mice by implantation of human fetal liver and thymus tissue to generate human T cells plus intravenous injection of autologous liver-derived CD34+ hematopoietic stem cells

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