Cytotoxic phenolic constituents ofAcer tegmentosum maxim (original) (raw)
Related papers
Plants are sources of large amount of drugs comparising to different groups such as Antispasmodics, Emetics, Anticancer and Antibacterial etc. This present study reports three different solvents extracts and aqueous prepared from four Indian plants belonging to different families collected from Adhiyamaan Botanical Garden krishnagiri district Tamilnadu. The preliminary phytochemical screening was performed from these extracts for the presence of Alkaloids, Tannins, Saponins, Phlobatannins, Flavanoids and Terpenoids. Result shows that the content of plants are below the toxic level for man. The presence of Alkaloids, Tannins, Saponins, Phlobatannins, Flavanoids, and Terpenoids in all these plants investigation indicates that they could be used in the treatment of burns and wounds. Finally the high Alkaloid Flavonoids and Terpenoids content of the plants suggest their antioxidant potential and justifies their therapeutic action which could be used in drug formation.
International Journal of Biosciences (IJB), 2020
Cancer presently exists as the major pathological state in developed and emergent nations equally which is characterized by the uncontrolled division of cells and is fatal. People prefer anticancer plant products to treat cancer due to the increased mortality related to undetected growth in addition to its toxic reactions to chemotherapy and radiotherapy. In recent years, eastern medicine provided a profitable substitute for allopathic medicine against cancer. There have been considerable researches on plants for treating cancer, and many of the plant products have been sold as anticancer medicine, depending on the conventional uses and experimental reports. The anticancer property of medicinal plants is due to their antioxidant activity which has been described in many reports. Thus, after isolation (by using chromatographic and crystallization techniques) and identification using LCMS spectra, IR, and NMR, many combinations of the active components can be prepared and should be further evaluated for their synergic effects. The development of a systemized dose and dosage procedure may perform an exceptional role in the cure of tumors. The rate at which cancer develops is a necessary and effective endeavor for the good health of human beings. Further investigations are required to analyze the mechanisms of anti-malignant action of active compounds from new plants and the use of standard herbal remedies.
Antioxidant and cytotoxic activities of Thai medicinal plants named
Keawpradub, N., Dej-adisai, S. and Yuenyongsawad, S. Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria Songklanakarin J. Sci. Technol., 2005, 27(Suppl. 2) : 455-467 The stems of Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria, collectively known in southern Thailand as Khaminkhruea, were sequentially extracted with petroleum ether, chloroform, methanol, and boiling water to afford 12 crude extracts. All extracts have been assessed for antioxidant activity against DPPH (1,1-diphenyl-2-picrylhydrazyl) radical and cytotoxic activity against brine shrimp and human cancer cell line MCF-7 (breast adenocarcinoma). Methanol extract of A. flava (AFM), and methanol and chloroform extracts of C. blumeanum (CBM and CBC) exhibited moderate antioxidant activity with EC 50 values of 25-55 µ µ µ µ µg/ml. Chloroform extracts of A. flava (AFC) and F. tinctoria (FTC), AFM, CBC and CBM showed pronounced cytotoxic activity against brine shrimp and MCF-7 cells with LC 50 and IC 50 values of 210-278 and 8-12 µ µ µ µ µg/ml, respectively. Bioassay-guided chemical investigation led to the isolation of berberine as a main compound of AFC, AFM, CBC and CBM. Palmatine and jatrorrhizine were found to be main alkaloids of FTC, and minor alkaloids of AFC, AFM, CBC and CBM. In addition, an ester triacontanyl caffeate was isolated for the first time from C. blumeanum (CBC). Chemical structures of the isolated ORIGINAL ARTICLE : Thai Herbs 456 Antioxidant and cytotoxic activities of A. flava, C. blumeanum and F. tinctoria Keawpradub, N., et al.
Ajuga turkestanica Rgl. Brig (Lamiaceae) is a medicinal plant from Uzbekistan. Methanol, chloroform, butanol, and water extracts as well as isolated phytoecdysteroids and iridoids were evaluated for their antioxidant, cytotoxic and antibacterial activities. Water and butanol extracts exhibited good antioxidant activity with IC 50 values of 7.24 ± 0.82 and 14.57 ± 1.64 µg/mL. The chloroform extract showed potent cytotoxic effects against the cancer cell lines HeLa, HepG-2, and MCF-7 with IC 50 values of 7.13 ± 0.85, 9.03 ± 0.92, and 10.77 ± 1.44 µg/mL, respectively. Compared to the extracts, isolated phytoecdysteroids and iridoids showed weak cytotoxic activity. The chloroform extract has antimicrobial properties even against multiresistant strains like Staphylococcus aureus MRSA 1000/93 and Streptococcus pyogenes ATCC 12344. The methanol and chloroform extracts of A. turkestanica were further investigated for their GLC-volatile components using GLC/FID and GLC/MS. Pregna-4,9 (11)-dien-20-ol-3-on-19-oic acid lactone (19.58%), 20methyl-pregna-5,17-dien-3β-ol (12.93%), 3,7-dioxocholan-24-oic acid (10.53%) and betulin (10.18%) were detected as the major compounds.
Cytotoxic activity screening of Bangladeshi medicinal plant extracts
Journal of Natural Medicines, 2014
The cytotoxic activity of 23 crude methanol extracts from 19 Bangladeshi medicinal plants was investigated against healthy mouse fibroblasts (NIH3T3), healthy monkey kidney (VERO) and four human cancer cell lines (gastric, AGS; colon, HT-29; and breast, MCF-7 and MDA-MB-231) using MTT assay. High cytotoxicity across all cell lines tested was exhibited by Aegiceras corniculatum (fruit) and Hymenodictyon excelsum (bark) extracts (IC 50 values ranging from 0.0005 to 0.9980 and 0.08 to 0.44 mg/mL, respectively). Fourteen extracts from 11 plant species, namely Clitoria ternatea (flower and leaf), Dillenia indica (leaf), Diospyros peregrina (leaf), Dipterocarpus turbinatus (bark and leaf), Ecbolium viride (leaf), Glinus oppositifolius (whole plant), Gnaphalium luteoalbum (leaf), Jasminum sambac (leaf), Lannea coromandelica (bark and leaf), Mussaenda glabrata (leaf) and Saraca asoca (leaf), were also significantly cytotoxic (IC 50 \ 1.0 mg/mL) against at least one of the cancer cell lines tested. More selectively, Avicennia alba (leaf), C. ternatea (flower and leaf), Caesalpinia pulcherrima (leaf), E. viride (leaf) and G. oppositifolius (whole plant) showed cytotoxicity only against both of the breast cancer cell lines (MCF-7 and MDA-MB-231). In contrast, C. ternatea (flower and leaf) exhibited high cytotoxic activity against MDA-MB-231 (IC 50 values of 0.11 and 0.49 mg/mL, respectively), whereas E. viride and G. oppositifolius whole plant extracts exhibited high activity against MCF-7 cells (IC 50 values of 0.06 and 0.15 mg/mL, respectively). The cytotoxic activity test results for 9 of the plant species correlate with their traditional use as anticancer agents, thus making them interesting sources for further drug development.
Isolation and characterization of phytoconstituents from Myanmar medicinal plants
2018
This thesis describes the isolation, the characterization and pharmacological activities of phytoconstituents from the Myanmar medicinal plants Streptocaulon tomentosum Wight & Arnott (Asclepiadaceae), Curcuma comosa Roxb. (Zingiberaceae) and Vitis repens Wight & Arm. (Vitaceae). Triterpenoids, cardenolides, lignanes, and steroidal saponines (compounds 1-20) including digitalopyranoside] (67), 17α-H-periplogenin-3-O-β-D-digitoxoside (11), 17α-Hperiplogenin-3-O-β-D-cymaroside (12), periplogenin glucoside (68), corchorusoside C (69), subalpinoside (70), (4R)-4-hydroxy-3-isopropyl pentyl-β-rutinoside (71), (R)-2-ethyl-3-methyl-butyl rutinoside (72), caffeic acid (73), 4,5-di-O-caffeoylquinic acid (74), and 2phenylethyl rutinoside (75) were isolated from roots of Streptocaulon juventas [Ueda et al., 2003a]. Lupeol acetate (4), lupeol (76) and 3β-acetyloxy urs-12-ene (2) were also obtained from roots of Streptocaulon juventas [Tam et al., 2002]. 2.2. Bioactivities of cardenolides and triterpenes 2.2.1. Pharmacological activities of cardenolides Cardenolides are C 23 steroid derivatives which are of special interest because of their cardiac activity; they are sometimes called cardiac glycosides. All cardenolides have a 3β-oxygen function, a 14 β-hydroxyl group and an α,β-unsaturated γ-lactone attached at 17β. The ABring junction is often cis as in digitoxigenin (17), but can also be trans as in uzarigenin (77). Cardenolides occur in several plant families including the Asclepiadaceae, the Apocynaceae, the Scrophulariaceae, the Celastraceae, and the Tiliaceae. The cardiac glycosides digitoxin (78) and digoxin (79) have been used for the treatment of heart failure for hundreds of years. These compounds are specific inhibitors of the plasma membrane bound Na + /K + ATPase, and there is much evidence which suggests that this inhibition of the enzyme activity is responsible for their cardiotonic as well as toxic effects [Akera & Brody, 1978; Repke, 1963; Skou, 1965]. Much of the earlier work on the pharmacological activities, especially anticancer activity, of cardiac glycosides has been carried out in either animals or in isolated organs derived from various species. In the 1960s clear inhibition of malignant cells of cardiac glycosides in vitro was reported [Shiratori, 1967]. In 1979, it was observed that breast cancer cells from women on digitalis had more benign characteristics than cancer cells from control patients not on these drugs [Stenkvist et al., 1979; 1980] and that five years after a mastectomy, the recurrence among patients not taking digitalis was 9.6 times higher than in patients on these drugs [Stenkvist et al., 1982]. In 1999, with this background, a 22-year follow-up of 175 patients with breast carcinoma, of which 32 were on digitalis treatment, when they acquired their breast carcinoma, have been made. It was observed that there was a lower death rate (6%) from breast carcinoma among the patients on digitalis, when compared with patients not on digitalis (34%) [Stenkvist, 1999].
Cytotoxic constituents from the seeds of Vietnamese Caesalpinia sappan
Pharmaceutical Biology, 2015
Context: Caesalpinia sappan Linn. (Leguminosae) has been used in folk medicines for the treatment of many diseases. The heartwood of this plant contains various phenolic components with interesting biological applications; however, the chemical and biological potentials of the seed of this plant have not been fully explored.
Journal of Research in Pharmacy, 2019
In continuation of our study of Sumatran plants and bioactivities of their constituents particularly their cytotoxic activities, we re-extracted lichen Stereocaulon graminosum Schaer (Stereocaulaceae), and isolated atranorin (1) and stictic acid (4).. These isolated compounds have been tested for their cytotoxic activities against human breast adenocarcinoma cancer cell (MCF-7) and human oral squamous carcinoma cancer cell (HSC-3) using MTT assay with a slight modification. Some methanolic extracts of the leaves of Elephantopus scaber, Piper betle, Andrographis paniculata, rhizomes of Boesenbergia pandurata, Alpinia galanga, Kaempferia galanga and isolated compounds; ethyl haematommate (2), olivatolic acid (3), deoxyelephantopin (5), andrographolide (6), hydroxychavicol (7), eugenol (8), curcumin (9), pinostrobin (10), pinocembrin (11), alpinetin (12), α-mangostin (13), angiopteroside (14), and stevioside (15) from Sumatran traditional medicinal plants have also been tested.