Sarcoidosis of the thyroid gland initially diagnosed as malignancy (original) (raw)
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Chronic Granulomatous Lesions After Thyroidectomy: Imaging Findings
American Journal of Roentgenology, 2005
OBJECTIVE. The purpose of this report is to describe the imaging appearance of granulomatous inflammation in the neck presenting as a late complication in patients who have undergone thyroidectomy for differentiated thyroid carcinoma. CONCLUSION. Granulomatous inflammation can occur as a palpable mass in the operative bed of asymptomatic patients who have undergone thyroidectomy for thyroid carcinoma. The diagnosis may be suggested when the lesion shows the sonographic appearance of a poorly defined hypoechoic lesion or lesions with a central echogenic nonshadowing focus, often within the sternocleidomastoid muscle. These lesions may appear as complex cystic masses on CT and MRI and may have increased activity on PET. Percutaneous biopsy can establish the diagnosis of an inflammatory lesion and can exclude underlying active infection and malignancy.
Idiopathic Necrotizing Granulomas of the Thyroid: Report of a Rare Case
Advancements in Case Studies, 2018
A 75 year old male presented to his physician with 6 months of fatigue, poor concentration, cold intolerance, generalized weakness and gait imbalance. He denied neck pain, preceding viral illness or hyperthyroid symptoms. Palpation revealed anon-tender stony hard thyroid. His TSH was 153mIU/L (reference 0.3-4.2) as compared to a normal level 6 months prior; and free T4 was 0.3ng/dL (reference 0.9-1.7). Thyroid peroxidase and thyro globulin antibodies were not elevated. He underwent partial left lobe resection at another institution which on histology showed necrotizing granulomas with multinucleated giant cells on a background of fibrosis and chronic lymphocytic inflammation (Figure 1A). QuantiFERON Gold and PPD skin tests for Tuberculosis were negative. Levothyroxine 100 micrograms daily was initiated for primary hypothyroidism, however the etiology of granulomas remained a mystery.
Journal of thyroid research, 2010
Introduction. We present a case of an 89-year-old female who attended our surgical endocrine clinic with a 3-month history of a left-sided neck lump. There was no past medical history of thyroid disease. Methods. Following examination and further investigation, including core biopsy, a diagnosis of plasma cell granuloma of the thyroid was made. Biochemical testing of thyroid function and Thyroid Peroxidase Antibody was in-keeping with an associated Hashimoto's thyroiditis. Results. The patient was treated conservatively with thyroxine and regularly seen in clinic. TSH levels improved and the lump showed signs of regression. Conclusion. Plasma cell granuloma of the thyroid is rare with only 16 previously reported cases. We present a new approach to management without the use of surgery or steroids. The literature is reviewed comparing clinico-pathological features and management of other reported cases.
Non neoplastic lesions of thyroid– Histopathological study
IP innovative publication pvt ltd, 2020
Introduction: Thyroid swellings are routinely encountered cases in clinical practice particularly among Asian countries as iodine deficiency plays a crucial etiological role in predominant cases of non neoplastic lesions. Thyroid swelling creates a major socioeconomic and health problem as they present as asymptomatic nodules many a times as firm swellings or as soft cystic in consistency masses. Thyroid gland lesions presents a large variety of pathological lesions. Incidence of non neoplastic lesions are more common than neoplastic lesions. Present study aims to know the spectrum of presentation of these non neoplastic lesions of thyroid. Materials and Methods: In the present study the data was analysed and a total of 209 cases of non neoplastic lesions of thyroid were studied. The study was carried out in the Department of Pathology of an Autonomous institute Government Medical college and hospital (RIMS), Raichur, India, for a period of 3 years with 2 years of retrospective and 1 year of prospective study respectively. Results: In the present study results collected were analysed and portrayed that out of 209 cases, higher incidence of Non neoplastic lesions were noted in 3rd decade and 4th decade of life, predominant number of the patients were diagnosed in females with 68.8% and when data was analysed, which showed that the female to male ratio was 2.3:1. Colloid goiter formed the major non neoplastic lesions having a total of 110 cases with 52.63% indicating more than half of the cases were colloid goitre, and was the most common non neoplastic lesion diagnosed histopathologically, next in line was multinodular goitre which was diagnosed in 82 cases having 39.23% of share, hashimoto’s thyroiditis was diagnosed in 10 individuals which constituted 4.79% of the total cases. Study also tabulated adenomatous hyperplasia with 3.35% of population which were associated with colloid goiter and multinodular goiter. Conclusion: Non neoplastic lesions of thyroid have varied clinical presentation and confirmation of these thyroid lesions can be done by histopathological study in correlation with clinical presentation. Present study is intended to evaluate the incidence and categorise histopathologically the types of non neoplastic lesions of the thyroid in this region.
Pattern of Thyroid Diseases - A Histopathological Study
The aim of this study is to describe the clinicopathological findings of thyroidectomy specimens. Setting: Bahrain Defence Force Royal Medical Services Hospital-Bahrain. Design: Retrospective Study. Method: This is a study of all cases of thyroidectomy specimens diagnosed from January 2000 to December 2004; all histology reports, clinical information and stained slides were reviewed. Thyroid diseases were grouped into different categories according to gender and age distribution. Result: One hundred and ten cases of thyroidectomy specimens were found, 84 females and 26 males with female: male ratio 3.2:1. Fifty cases (45.5%) of Nodular goiter were seen, it was the most common thyroid disease followed by malignancy 26 (24%), follicular adenoma 17 (15.5%), primary thyrotoxicosis 9 (8%) and Hashimoto's thyroiditis 8 (7%). Age range for colloid goiter was 19-67, malignancy 21-82, follicular adenoma 20-69, primary thyrotoxicosis 20-42 and Hashimoto's thyroiditis 20-56. Colloid goiter had a peak at age group 31-40 years. Papillary carcinoma was the commonest malignant thyroid tumour (25 cases). All cases of Hashimoto's thyroiditis were females (100%). Primary thyrotoxicosis was the only thyroid disease with male: female ratio 2:1. Conclusion: In this study, Thyroid malignancy accounted for 24% of patients with thyroid swelling who underwent surgery. Identification of thyroid malignancy requires proper diagnostic tools including ultrasonography, reliable FNAC technique and proper pathological examination.