A Novel Pseudo-Component Model to Assess the Viscoelastic Behavior of Scaffolds Used in Tissue Engineering (original) (raw)

Abstract

Most biological tissues and scaffolds used in tissue regeneration display time-dependent and load-history-dependent mechanical behavior. Soft tissues such as muscles, tendons, ligaments, fascia, nerves, fibrous tissues, fat, blood vessels, and synovial membranes display nonlinear material behavior and are found to exhibit viscoelastic character. Further, porous polymeric biodegradable structures utilized in tissue regeneration also show viscoelastic behavior. A number of models have been developed to assess the nonlinear viscoelastic behavior of soft materials. The most common phenomenological model has been the Quasi Linear Viscoelastic (QLV) model, introduced by Fung and later modified by many others according to comply with specific test or material requirements. The QLV theory assumes that the stress relaxation behavior of soft tissues can be expressed as a convolution integral of a strain independent reduced relaxation function and a nonlinear instantaneous stress function resu...

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