Conformational basis for the Li+-induced leak current in the rat  -aminobutyric acid (GABA) transporter-1 (original) (raw)

Abstract

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The study investigates the Li+-induced leak current in the GABA transporter-1 (GAT-1), highlighting the distinct conformational states of the transporter during ion translocation. It explains how Li+ can bind to specific sites within the transporter, altering its conformation and affecting ion permeability. The findings suggest key interactions between Na+ and Li+ in the transport process, proposing a model that correlates with observed leak currents and implicates structural modifications in the transport mechanism.

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