A Balance between B Cell Receptor and Inhibitory Receptor Signaling Controls Plasma Cell Differentiation by Maintaining Optimal Ets1 Levels (original) (raw)

The regulation of B cell differentiation into plasma cells is crucial for maintaining the balance between effective immune responses and autoimmunity. This study highlights the importance of Ets1 levels in this process, demonstrating that signaling from B cell receptors (BCR) and inhibitory receptors works in tandem to control Ets1 expression through the action of the phosphatase SHP1. Findings indicate that SHP1 not only regulates Ets1 but that maintaining optimal Ets1 levels is key to preventing excessive differentiation of autoreactive B cells. The paper illustrates that disruptions in this balance, particularly through loss of negative signaling, can lead to increased autoantibody production and susceptibility to autoimmune diseases.