Quantitative Analyses of ROS and RNS Production in Breast Cancer Cell Lines Incubated with Ferrocifens (original) (raw)

This study examines the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in hormone-dependent and -independent breast cancer cell lines treated with various ferrocifen compounds. The synthesized hydroxyferrocifens combine ferrocene with the tamoxifen structure, offering improved anti-proliferative effects compared to traditional therapies. Key findings indicate a significant increase in ROS and RNS production upon treatment, suggesting that these compounds may induce cytotoxicity through oxidative stress mechanisms.