A mechanosensitive ion channel regulating cell volume (original) (raw)

This research explores the role of mechanosensitive ion channels (MSCs) in regulating cell volume, specifically focusing on the regulatory volume decrease (RVD) process in different cell types. Utilizing a microfluidic device and the peptide GsMTx4, the study demonstrates that MSCs are involved in RVD, with GsMTx4 inhibiting this process significantly in normal rat kidney (NRK-49F) cells while having no effect on primary rat astrocytes and Madin-Darby canine kidney (MDCK) cells. The findings reveal at least two distinct types of volume sensors, suggesting a specialized role for MSCs in cell volume regulation.