Practicality of Tetragonal Nano-Zirconia as a Prospective Sorbent in the Preparation of 99 Mo/99m Tc Generator for Biomedical Applications (original) (raw)

The feasibility of using tetragonal nano-zirconia (t-ZrO 2 ) as an effective sorbent for developing a 99 Mo/ 99m Tc chromatographic generator was demonstrated. The structural characteristics of the sorbent matrix were investigated by different analytical techniques such as XRD, BET surface area analysis, FT-IR, TEM etc. The material synthesized was nanocrystalline, in tetragonal phase with an average particle size of *7 nm and a large surface area of 340 m 2 g -1 . The equilibrium sorption capacity of t-ZrO 2 is >250 mg Mo g -1 . The present study indicates that 99 Mo is both strongly and selectively retained by t-ZrO 2 at acidic pH and 99m Tc could be readily eluted from it, using 0.9% NaCl solution. A 9.25 GBq (250 mCi) t-ZrO 2 based chromatographic 99 Mo/ 99m Tc generator was developed and its performance was repeatedly evaluated for 10 days. 99m Tc could be eluted with >85% yield having acceptable radionuclidic, radiochemical and chemical purity for clinical applications. The compatibility of the product in the preparation of 99m Tc labeled formulations such as 99m Tc-EC and 99m Tc-DMSA was evaluated and found to be satisfactory.

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