Early-onset sensorineural hearing loss in Lassa fever (original) (raw)
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Sensorineural hearing loss in Lassa fever: two case reports
2016
Introduction: Lassa fever is an acute arena viral haemorrhagic fever with varied neurological sequelae. Sensorineural hearing loss is one of the rare complications which occur usually during the convalescent stage of the infection. Case presentation: The cases of two female patients aged 19 and 43 years old, respectively, with clinical features suggestive of Lassa fever and confirmed by immunoserological/Lassa-virus-specific
Imported Case of Lassa Fever in Sweden With Encephalopathy and Sensorineural Hearing Deficit
Open forum infectious diseases, 2016
We describe an imported case of Lassa fever with both encephalopathy and bilateral sensorineural hearing deficit. Absence of fever during hospitalization, initially nonspecific symptoms, and onset of hearing deficit in a late stage of disease probably contributed to delayed diagnosis (14 days after admittance to hospital). The pathogenesis of neurological manifestations of Lassa fever is poorly understood and no specific treatment was given. A total of 118 personnel had close contact with the patient, but no secondary cases occurred. This case highlights the importance of considering Lassa fever as a differential diagnosis in patients with recent travel to endemic areas.
Pharma Springs Publication, 2023
Lassa fever (LF) is indeed a significant public health concern, particularly in parts of Africa. This viral infection, caused by the Lassa virus (LASV), is known for its high prevalence and fatality rates in certain regions, including North Africa. Research indicates that the estimated case fatality rate of Lassa fever in North Africa ranges from 16.5% to as high as 50% in some areas. For example, in Plateau State, North Central Nigeria, the case fatality rate was reported to be 57%. Across Western Africa, up to 300,000 new infections and 5,000 deaths are estimated to occur annually, with fatality rates reaching up to 25.4% in recent Nigerian outbreaks. The high fatality rates, especially among hospitalized patients, highlight the severity of this disease. For instance, in Nigeria, the overall mortality rate has been reported to be around 19%, with higher rates among health workers.
Mortality Among Lassa Fever Patients: A Systematic Review
American Journal of Internal Medicine, 2021
Background: Lassa fever is a disease of public health importance because of its morbidity and associated mortality and also because of its potential for residual morbidity such as hearing loss and social stigma. Knowledge of the mortality among Lassa fever patients is one way of assessing the effectiveness of the current strategies employed in Lassa fever management. This article is aimed at reviewing mortalities among Lassa fever patients. Methods: The relevant articles for the review were searched and obtained through the PubMed database. Data of interest were confirmed cases of Lassa fever, number of deaths and case fatality rates. Findings: All the studies reviewed were carried out in the Lassa fever endemic zone of West Africa. The case fatality rates in Lassa fever ranged from 24% to 61%, with a mean of 36%. More cases of Lassa fever and more deaths occurred during Lassa fever outbreaks. Patient’s age, co-existing medical conditions as well as complications arising from Lassa ...