Design and In Vitro Interference Test of Microwave Noninvasive Blood Glucose Monitoring Sensor (original) (raw)
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IET, 2018
This paper presents a new approach for measuring blood glucose level using microwave technique in a non-invasive technique. A microwave resonator was designed, simulated, fabricated, and used to measure frequency shifts caused by varying standard glucose solution, and blood glucose through the finger of the human volunteer before and after high glucose meal consumption. The device was able to measure and differentiate the reflection coefficients of standard glucose solutions ranging from 60mg/dl to 110 mg/dl, and between blood glucose of human subject before and after high glucose content meal consumption. The numerical results show the prospects of the microwave technique for monitoring blood glucose levels within the normal to a diabetic condition in humans. The proposed method can potentially provide a practical application of a low-cost and fast monitoring of the glucose levels in a non-invasive way for diabetic patients. Also, the device is sensitive and could detect as low as 0.1g/l change in glucose concentration.
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We measured the glucose concentration by using the real-time electromagnetic interaction between probe-tip and glucose solution using a microwave biosensor. The microwave biosensor, consisting of a dielectric resonator coupled to the probe-tip, allows observation of the small variation of the glucose concentration changes in the ranges of 0-300 mg/ml by measuring the microwave reflection coefficient S 11 . We could observe the concentration of glucose with a detectable resolution up to 1 mg/ml at an operating frequency of about f = 4-5 GHz. The change of the glucose concentration is directly related to the change of the reflection coefficient due to the electromagnetic interaction between the microwave resonator and the glucose solution. The operational principal is explained by the plane-wave solution model. The measured signal-to-noise ratio was about 37 dB, and the minimum detectible signal was about 0.003 dB/(mg/ml). A glucose biosensor using a microwave resonator with probe provides a unique approach for glucose real-time monitoring.
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Journal of Physics: Conference Series, 2013
In this paper a simulation of a microwave resonator sensor for constructing a noninvasive blood glucose meter is presented. A relationship between changes of the dielectric permittivity of the blood and the frequency response of S parameters of the sensor is observed. This can lead to a measuring procedure in which the glucose level present has a correlation with the value of the frequency resonance of the sensor. The test bank consists of a planar spiral microwave resonator over which the individual under test places his/her finger. This modifies the initial frequency resonance of the resonator because of the change produced in the measuring procedure over the dielectric permittivity of the resonator. Simulations show a correlation between dielectric permittivity blood changes, and changes in the value of the frequency resonance, in the frequency response of S parameters of the resonator.
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Noninvasive glucose monitoring system has been a scrumptious field of research for last three decades. With the advancement of technology and equipment, many non-invasive glucose monitoring devices have been evolved. Some of them are promising technology among the others. However, several published researches hide much of the research data. Even many of them do not have new updates afterwards their promising approach. Moreover, limitations and negative reviews regarding the glucose monitoring devices available in the market, have been reported. Thus, the search for the next generation of pain free, reliable, cost effective glucose monitoring technique is still alive. Researchers are now more interested in the study of microwave or electromagnetic sensing technique in the industrial, scientific and medical (ISM) radio frequency bands which detects the dielectric parameters of the blood and interstitial fluid, caused by the changes in glucose concentration level as a possible approach...