Occult oncocytoma of the lacrimal sac (original) (raw)
Related papers
Recurrent Oncocytoma of the Lacrimal Sac
Case reports in pathology, 2022
Oncocytoma of the lacrimal sac is an extremely rare tumor. In this report, we present the case of an 82-year-old woman who presented with swelling in the region of the lacrimal sac. Systemic examination and ophthalmic examination of both eyes were unremarkable. Computed tomography of the brain and orbits revealed a mass lesion involving the right lacrimal sac with expansion of the related nasolacrimal duct. Neither bone destruction nor tissue invasion was observed. Right external dacryocystectomy and debulking of the tumor were performed. Histopathological examination of the surgical specimen showed oncocytic cells arranged in an adenomatous fashion, and a diagnosis of benign oncocytoma was made. Three years later, the same patient presented with a similar complaint that was pathologically proven to be a recurrent benign oncocytoma of the lacrimal sac.
Oncocytoma of the Lacrimal Gland: Case Report and Review of the Literature
Orbit, 2006
Objective: Oncocytomas of the lacrimal gland are rare tumors. We report the eighth case in the literature. Design: Interventional case report and literature review. Intervention: Complete ophthalmologic and systemic examination followed by excisional biopsy and histopathologic examination. Results: A 40-year-old Hispanic woman was evaluated for a right-sided upper eyelid edema and pain on ocular motility. A month earlier an outside ophthalmologist had performed a conjunctival biopsy that disclosed chronic inflammation. Computed tomography and magnetic resonance imaging of brain and orbit demonstrated a right intraorbital extraconal soft tissue density mass that involved the lacrimal gland, upper eyelid and encroached both the superior oblique and superior rectus muscles. Histopathology showed a benign oncocytoma that replaced most of the lacrimal gland. Conclusion: Although rare, oncocytomas should be included in the differential diagnosis of any lacrimal gland tumors.
Oncocytoma of the lacrimal gland diagnosed initially by fine-needle aspiration cytology
Diagnostic Cytopathology, 2009
Oncocytomas are benign tumors that infrequently involve ocular adnexa. We describe a case of oncocytoma of the lacrimal gland which was initially diagnosed by fine-needle aspiration cytology. An 83-year-old patient presented to the cytology laboratory with a peripunctal mass in the right eye. The tumor was aspirated. The cytoplasm of the tumor cells was rich in eosinophilic granules. The initial cytological diagnosis was oncocytoma. The tumor was then completely excised and the histological diagnosis confirmed the initial cytological one. Oncocytoma is a rare entity which must be considered in differential diagnosis of a peripunctal mass in elderly patients. The literature was reviewed confirming the rarity of such a presentation and the novelty of this case. Cytological criteria of malignancy are not yet established. Diagn.
Oncocytoma of the lacrimal gland: a case report
Here we describe a rare case of a benign tumor in the lacrimal gland of a healthy 4-year-old girl. Mild proptosis was the only abnormality observed on clinical exa- mination. Magnetic resonance imaging of the right orbit revealed an oval, solid, well-circumscribed, homogeneous mass extending from the lacrimal gland and measuring 2.5 × 2.3 × 1.7 cm without any evidence of invasion into adjacent bones. The lesion was surgically excised and histological analyses defined the diagnosis of oncocytoma of the lacrimal gland. Although rare, oncocytoma should be included in the differential diagnosis of lacrimal gland tumors.
Tumors of the Lacrimal Sac: Three case reports
Community Based Medical Journal
Lacrimal Sac tumors are extremely rare and potentially life threating. It may be primary, secondary and metastasis from distant organ. Lacrimal sac tumors may be broadly classified into epithelial (72%), mesenchymal (12%), lymphoproliferative (11%) and melanocytic (04%). About 72% are malignant; tend to be locally invasive with high recurrence rate. To report three cases of rare primary lacrimal sac tumors. We evaluated three rare case reports on primary lacrimal sac tumors in two tertiary eye hospitals in Bangladesh. 46 year old female, 36 year old male, and a 21-year-old young male, patients presented with mass in the lacrimal sac area. Two of them underwent deep incision biopsy and histopathology revealed Low grade extranodal marginal zone lymphoma (ENMZL). One patient was treated with Radiotherapy and another one with 6-Cycles of CHOP chemotherapy(Cyclophosphamide, Hydroxydaunorubicin, Oncovin,Prednisone). One patient underwent excision biopsy and histopathology reported lacrima...
Nonepithelial Tumors of the Lacrimal Sac
Ophthalmic Plastic and Reconstructive Surgery, 1996
Lacrimal sac tumors are rare and mostly of epithelial origin. We conducted a clinicopathologic study of 35 cases of nonepithelial tumors of the lacrimal sac. These tumors in cluded 13 fibrous histiocytomas, one hemangiopericytoma, one lipoma, ten lymphoid lesions, eight malignant melanomas, one granulocytic sarcoma, and one neurofibroma. Ex cept for one 9-year-old child with fibrous histiocytoma, all neoplasms involved adults (age range, 27 to 90 years). The most common initial signs and symptoms were epiphora, chronic inflammation, or lacrimal mass. A bloody nasal discharge and bleeding from the punctum occurred in a patient with malignant melanoma. In none of the patients was the clinical diagnosis of a lacrimal sac tumor made preoperatively. Some of the nonepithe lial neoplasms of the lacrimal sac can be lifethreatening; therefore, early diagnosis and treatment are important. LACRIMAL SAC OBSTRUCTION is usually the result of inflammation, congenital malformation, and trauma. On rare occasions, tumors of the lacri mal sac may also obstruct tear drainage. More over, lacrimal sac tumors can be life-threaten ing; therefore, early diagnosis and treatment are important. Three hundred seventy-five true lacrimal sac tumors have been reported in the world litera ture as series of cases 111 and as solitary case reports. 1240 Primary epithelial neoplasms were the most common tumors of the lacrimal sac,
Oncology letters, 2017
The aim of the present study was to report the genetic and immunohistochemical profile of a rare case of lacrimal gland oncocytoma. A 20-year-old male underwent magnetic resonance imaging (MRI) due to viral encephalitis. Notably, the MRI revealed a multicystic tumor in the left lacrimal gland. A lateral orbitotomy was performed and the tumor was completely excised. Four months following surgery, the patient was free of symptoms. Histopathologically, the tumor was composed of large, eosinophilic and polyhedral cells with small round nuclei. The tumor cells stained strongly for antimitochondrial antibody MU213-UC, cytokeratin (CK) 5/6, CK 7, CK 17, CK 8/18 and CK 19. The final diagnosis was an oncocytoma of the lacrimal gland without any signs of malignancy. Array-based comparative genomic hybridisation demonstrated a gain of one copy of chromosome 8 and loss of one copy of chromosome 22 as the sole genomic imbalances. These chromosomal alterations have not previously been identified ...
Klinicka onkologie, 2016
Background: Lacrimal sac tumors are very rare and are often missed because patients present with features consistent with chronic dacryocystitis. Squamous cell carcinoma is the common est lacrimal sac malignancy. Although primary mucoepidermoid carcinomas of the lacrimal sac are rare, they are locally aggressive. Furthermore, their proximity to vital structures and the skull base makes them potentially lifethreatening. Multidisciplinary management is required, and wide excision followed by chemoradiation is the recommended treatment. Case: Here, we report a 65yearold male who presented with watering eyes and a mass in the region of the medial canthus. A dia gnosis of primary mucoepidermoid carcinoma of the lacrimal sac was made, and the case was managed successfully with radical surgery and reconstruction. The tumor was resected using the extended LynchHowarth incision and the resulting defect was reconstructed using a forehead flap. Histopathological examination of the excised specimen revealed mucoepidermoid carcinoma. Immunohistochemical analysis revealed that the speci men was positive for epithelial growth factor receptor and Ki67 protein. The patient was refe rred for postoperative chemoradiation. The literature is reviewed and pathological features, including immunohistochemistry are discussed. Conclusion: Primary mucoepidermoid carci noma of the lacrimal sac is a rare, locally aggressive tumor that is often mistaken for dacryocys titis. The treatment of choice is radical surgery followed by chemoradiation.