Prevalence, incidence, and risk factors of intestinal parasites in Danish primary care patients with irritable bowel syndrome (original) (raw)
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Risk Factors and Diagnosis of Intestinal Parasitic Infections in Irritable Bowel Syndrome Patients
Journal of the Egyptian Society of Parasitology, 2018
Irritable bowel syndrome (IBS) is still an ambiguous disorder of the gastrointestinal function. Several theories have been postulated as regard its underlying patho-physiology. Infection with intestinal parasites has been evaluated as a possible etiology with contradictory results. This study compared IBS cases with normal population in Fayoum Governorate as regard infection with parasites, and to detect their possible associated risk factors. Stool samples were parasitologically examined by concentrated sedimentation, stained with Lugol's iodine, trichrome. The RIDA ® QUICK Cryptosporidium/Giardia/Entamoeba Combi kits were applied. Stool samples were cultured on Jones and Loeffler's slope media for detection of Blastocystis spp. & D. fragilis, respectively. Blastocystis spp., D. fragilis & Cryptosporidium were the commonest parasites in the examined samples. Blastocystis spp. was the only parasite significantly associated with IBS. Contact with animals was a common risk factor for the three prevalent parasites. Low socioeconomic standard was a risk for Blastocystis & Cryptosporidium infections as well as consumption of contaminated food and/or drink was associated with Blastocystis infection.
2020
Irritable bowel syndrome (IBS) is still an ambiguous disorder of the gastrointestinal function. Several theories have been postulated as regard its underlying patho-physiology. Infection with intestinal parasites has been evaluated as a possible etiology with contradictory results. This study compared IBS cases with normal population in Fayoum Governorate as regard infection with parasites, and to detect their possible associated risk factors. Stool samples were parasitologically examined by concentrated sedimentation, stained with Lugol's iodine, trichrome. The RIDA ® QUICK Cryptosporidium/Giardia/Entamoeba Combi kits were applied. Stool samples were cultured on Jones and Loeffler’s slope media for detection of Blastocystis spp. & D. fragilis, respectively. Blastocystis spp., D. fragilis & Cryptosporidium were the commonest parasites in the examined samples. Blastocystis spp. was the only parasite significantly associated with IBS. Contact with animals was a common risk factor ...
. Protozoan parasites in irritable bowel syndrome- A casecontrol study
Protozoan parasites in irritable bowel syndrome: A casecontrol study, 2017
AIM To investigate the putative role of protozoan parasites in the development of irritable bowel syndrome (IBS). METHODS The study included 109 IBS consecutive adult patients fulfilling the Rome Ⅲ criteria and 100 healthy control subjects. All study subjects filled a structured questionnaire, which covered demographic information and clinical data. Fresh stool samples were collected from patients and control subjects and processed within less than 2 h of collection. Iodine wet mounts and Trichrome stained smears prepared from fresh stool and sediment concentrate were microscopically examined for parasites. Blastocystis DNA was detected by polymerase chain reaction, and Cryptosporidium antigens were detected by ELISA. RESULTS A total of 109 IBS patients (31 males, 78 females) with a mean age ± SD of 27.25 ± 11.58 years (range: 16-60 years) were enrolled in the study. The main IBS subtype based on the symptoms of these patients was constipation-predominant (88.7% of patients). A hundred healthy subjects (30 males, 70 females) with a mean ± SD age of 25.0 ± 9.13 years (range 18-66 years) were recruited as controls. In the IBS patients, Blastocystis DNA was detected in 25.7%, Cryptosporidium oocysts were observed in 9.2%, and Giardia cysts were observed in 11%. In the control subjects, Blastocystis, Cryptosporidium and Giardia were detected in 9%, 0%, and 1%, respectively. The difference in the presence of Blastocystis (P = 0.0034), Cryptosporidium (P = 0.0003), and Giardia (P = 0.0029) between IBS patients and controls was statistically significant by all methods used in this study. CONCLUSION Prevalence of Blastocystis, Cryptosporidium and Giardia is higher in IBS patients than in controls. These parasites are likely to have a role in the pathogenesis of IBS.
Frequency of Intestinal Parasites Among Sudanese Patients with Irritable Bowel Syndrome
American Journal of Health Research
The objective of this case control study is to identify the relationship between intestinal parasitic infection and Irritable Bowel Syndrome (IBS) among Sudanese patients. Method: Two hundred patients diagnosed with irritable bowel syndrome (IBS) and were attended Health Facilities at Khartoum State were enrolled, together with 99 apparently healthy controls. Patients were classified into three groups (IBS-all types, IBS with diarrhea (IBS-D), and IBS with constipation (IBS-C)). Stool specimens were collected form study population and all were subjected to microscopic examination following wet saline preparation, formal-ether concentration technique, Z. N stain, and in vitro cultivation in Locke egg medium. Results: Intestinal parasites were detected in 32% (64/200) of IBS-all types; and in 16.2% (16/99) of control group (P. value 0.005). For patients, 20 (10%) were positive for the Entamoeba cyst, 3 (1.5%) Giardia lamblia cysts, and 41 (20.5%) were positive for Blastocystis hominis cyst. For control, Entamoeba species were detected in 10 (10.1%), G. lambelia one case (1.1%), and B. hominis in 5 (5.2%). Blastocystis hominis was significantly prevalent among IBS-all types than the control group (P. value 0.02). It is more frequent among patients with IBS-D than those with IBS-C (P. value 0.001). Conclusion: This study concluded that, there is a statistical association between presence of intestinal parasites and IBS on study population. Blastocystis hominis was found more frequently detected parasite, and it was found significantly associated with IBS-diarrhea.
Parasites in Mexican patients with irritable bowel syndrome: a case-control study
Parasites & Vectors, 2010
One hundred and fifteen patients with symptoms suggestive of irritable bowel syndrome (IBS) according to Rome III criteria and 209 patients with gastrointestinal symptoms different from IBS (control) were identified through medical records from the Gastroenterology Clinic of the "Dr. Manuel Gea Gonzalez General Hospital" from January 2008 to March 2010. No statistical differences in IBS data as compared with control groups were observed except in bloating, that was more frequent in the IBS group (P = 0.043). Although the pathogenicity of specific intestinal protozoa could not be demonstrated due to lack of association with the development of gastrointestinal symptoms, Blastocystis spp, in the IBS group, exhibited a trend of association to diarrhoea (odds ratio = 2.73, 95% confidence interval = 0.84-8.80, P = 0.053), while having any parasite and diarrhoea was significant (odds ratio = 3.38, 95% confidence interval = 1.33-8.57, P = 0.008). The association between Blastocystis and diarrhoea in IBS patients although not conclusive is an interesting finding; nonetheless more extensive case-controlled studies are required to clearly define the role of some "non-pathogenic" parasites in intestinal disease and IBS.
Parasitology Research, 2010
Studies have suggested a possible role for Blastocystis hominis and Dientamoeba fragilis in the etiology of irritable bowel syndrome (IBS). We studied the prevalence of B. hominis and D. fragilis in patients with IBS-diarrhea (IBS-D). Three hundred and thirty patients were enrolled, 171 (52%) with IBS-D and 159 (48%) were controls, respectively. Stool microscopy, culture, and polymerase chain reaction (PCR) for B. hominis and D. fragilis were done. B. hominis was positive by stool microscopy in 49% (83/171) of IBS compared to 24% (27/159) in control (p < 0.001). B. hominis culture was positive in 53% (90/171) in IBS compared to 16% (25/159) in control (p < 0.001). B. hominis PCR was positive in 44% (75/171) in IBS compared to 21% (33/159) in control (p < 0.001). D. fragilis microscopy was positive in 3.5% (6/171) in IBS-D compared to 0.6% (1/159) in control (p = 0.123). D. fragilis culture was positive in 4% (7/171) in IBS compared to 1.3% (2/159) in control (p = 0.176). D. fragilis PCR was positive in 4% (6/171) in IBS-D compared to 0% (0/159) in control (p = 0.030). B. hominis is common, while D. fragilis was less prevalent in our patients with IBS-D. B. hominis and D. fragilis culture had a better yield compared to stool microscopy and PCR.
International Journal for Parasitology, 2007
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder in which abdominal pain is associated with a defect or a change in bowel habits. Gut inflammation is one of the proposed mechanisms of pathogenesis. Recent studies have described a possible role for protozoan parasites, such as Blastocystis hominis and Dientamoeba fragilis, in the etiology of IBS. Dientamoeba fragilis is known to cause IBS-like symptoms and has a propensity to cause chronic infections but its diagnosis relies on microscopy of stained smears, which many laboratories do not perform, thereby leading to the misdiagnosis of dientamoebiasis as IBS. The role of B. hominis as an etiological agent of IBS is inconclusive, due to contradictory reports and the controversial nature of B. hominis as a human pathogen. Although Entamoeba histolytica infections occur predominately in developing regions of the world, clinical diagnosis of amebiasis is often difficult because symptoms of patients with IBS may closely mimic those patients with non-dysenteric amoebic colitis. Clinical manifestations of Giardia intestinalis infection also vary from asymptomatic carriage to acute and chronic diarrhoea with abdominal pain. These IBS-like symptoms can be continuous, intermittent, sporadic or recurrent, sometimes lasting years without correct diagnosis. It is essential that all patients with IBS undergo routine parasitological investigations in order to rule out the presence of protozoan parasites as the causative agents of the clinical signs.
2021
The objective of this study was to investigate the prevalence of intestinal parasites and the possible association between irritable bowel syndrome (IBS) and parasitic infections. The study included 100 IBS patients and 100 healthy control subjects. All study subjects filled a structured questionnaire, which covered demographic information and clinical data. Fresh stool samples were collected from patients and control subjects and processed during the same day of collection. Iodine wet mounts and trichrome stained smears prepared from fresh stool and sediment concentrates were microscopically examined for intestinal parasites. Patients attended private gastroenterology clinics and those found to have IBS (45 males and 55 females) were then selected in this study. The healthy subjects (50 males, 50 females) were recruited as controls. In the IBS patients, Blastocystis sp. was detected in 57% and Giardia sp. cysts were observed in 43%. In the control subjects, Blastocystis sp. was detected in 12% and Giardia sp. cysts were observed in 20%. These parasites were found either alone or with other parasites. Only the differences in the presence of Blastocystis (P=0.0001) and Giardia (P=0.0006) between IBS patients and controls were statistically significant. Abdominal pain and blotting were the leading symptoms in IBS patients and controls. Prevalence of Blastocystis and Giardia was higher in IBS patients than in controls. These parasites are likely to have a role in the pathogenesis of IBS. The findings of the study support a possible link between parasitic infections and IBS.
Irritable bowel syndrome and intestinal parasites: a view from South America
Revista de gastroenterología del Perú : órgano oficial de la Sociedad de Gastroenterología del Perú
Irritable bowel syndrome (IBS) is a functional gastrointestinal disorder of uncertain etiology. Several studies have proposed the possible role of intestinal parasites in the pathogenesis of IBS. We aimed to summarize the epidemiological studies that describe a possible link between intestinal parasites and IBS, with special interest in endemic areas for intestinal parasitism such as South America. A comprehensive review of the literature was conducted by using the keywords: irritable bowel syndrome, intestinal parasites, protozoan infection, soil-transmitted helminths and South America. Giardia lamblia may cause IBS symptoms that can persist several years after effective treatment. Dientamoeba fragilis can cause IBS-like symptoms, but low sensitive parasitological techniques may fail to detect it. Entamoeba histolytica can cause a chronic non-dysenteric colitis, but several studies have failed to find an association with IBS. The role of Blastocystis hominis in IBS remains controve...