Peroxisome Proliferation and Lipid Peroxidation in Rat Liver1 (original) (raw)

Male F344 rats were fed a diet containing the peroxisome proliferators 2-(4-(2,2-dichlorocyclopropyl)phenoxy)-2-methyl- propionic acid (ciprofibrate (0.025%)) or (4-chloro-6-(2,3-xyli- dino)-2-pyrimidinylthio)acetic acid (Wy-14643 (0.1%)) for up to 14 months to determine whether hepatic peroxisome prolifera tion caused by these agents results in the induction of membrane lipid peroxidation in the liver. Peroxidative damage of membrane lipids from whole liver, postnuclear, heavy-particle, microsomal,