Synthesis of (E)- and (Z)-fluoro-olefin analogues of potent dipeptidyl peptidase IV inhibitors (original) (raw)
Fluoroolefins as amide bond mimics in dipeptidyl peptidase IV inhibitors
Jackie Shang
Bioorganic & Medicinal Chemistry Letters, 2008
View PDFchevron_right
γ-Amino-Substituted Analogues of 1-[( S )-2,4-Diaminobutanoyl]piperidine as Highly Potent and Selective Dipeptidyl Peptidase II Inhibitors
Ingrid Demeester
Journal of Medicinal Chemistry, 2004
View PDFchevron_right
Discovery of potent and selective β-homophenylalanine based dipeptidyl peptidase IV inhibitors
Edward Gonzalez
Bioorganic & Medicinal Chemistry Letters, 2004
View PDFchevron_right
Application of the Dipeptidyl Peptidase IV (DPPIV/CD26) Based Prodrug Approach to Different Amine-Containing Drugs
María-josé Camarasa
Journal of Medicinal Chemistry, 2010
View PDFchevron_right
Design, Synthesis, and SAR of Potent and Selective Dipeptide-Derived Inhibitors for Dipeptidyl Peptidases
Koen Augustyns, Ingrid Demeester
Journal of Medicinal Chemistry, 2003
View PDFchevron_right
Design and synthesis of novel 2-pyridone peptidomimetic falcipain 2/3 inhibitors
Neil Berry
Bioorganic & medicinal …, 2008
View PDFchevron_right
Development of potent and selective dipeptidyl peptidase II inhibitors
Ingrid Meester, Anne-marie Lambeir
Bioorganic & Medicinal Chemistry Letters, 2002
View PDFchevron_right
(2S,4S)-1-[2-(1,1-Dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: A potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
Chiung-tong Chen
Bioorganic & Medicinal Chemistry Letters, 2010
View PDFchevron_right
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: Synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Stephen J Orena
Bioorganic & Medicinal Chemistry Letters, 2007
View PDFchevron_right
Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125
Jason Yano
Bioorganic & Medicinal Chemistry, 2011
View PDFchevron_right
Novel amidino-substituted benzimidazoles: Synthesis of compounds and inhibition of dipeptidyl peptidase III
Dejan Agić
Bioorganic Chemistry, 2007
View PDFchevron_right
Molecular modeling of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile as a dipeptidyl peptidase IV (DPP4) inhibitor
Sabarudin Ombe
Journal of Applied Pharmaceutical Science, 2018
View PDFchevron_right
Dipeptidyl peptidase IV inhibitors derived from β-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
Gurudeeban Selvaraj
Bioorganic & Medicinal Chemistry Letters, 2005
View PDFchevron_right
Synthesis and biological evaluation of homopiperazine derivatives with β-aminoacyl group as dipeptidyl peptidase IV inhibitors
Duck Lee
Bioorganic & Medicinal Chemistry Letters, 2008
View PDFchevron_right
(3,3-Difluoro-pyrrolidin-1-yl)-[(2S,4S)-(4-(4-pyrimidin-2-yl-piperazin-1-yl)-pyrrolidin-2-yl]-methanone: A potent, selective, orally active dipeptidyl peptidase IV inhibitor
Stephen J Orena
Bioorganic & Medicinal Chemistry Letters, 2009
View PDFchevron_right
Synthesis of a fluoroalkene peptidomimetic precursor of N-acetyl-l-glutamyl-l-alanine
Peter Goekjian
2007
View PDFchevron_right
Synthesis, biological assay in vitro and molecular docking studies of new imidazopyrazinone derivatives as potential dipeptidyl peptidase IV inhibitors
Mingjie Zhu
European Journal of Medicinal Chemistry, 2010
View PDFchevron_right
Pyrrolidides: synthesis and structure-activity relationship as inhibitors of dipeptidyl peptidase IV
Koen Augustyns, Ingrid Demeester
European Journal of Medicinal Chemistry, 1997
View PDFchevron_right
Design, Synthesis, Qsar Studies and Biological Evaluation of Novel Triazolopiperazine Based B-Amino Amides as Dipeptidyl Peptidase-IV (DPP-IV) Inhibitors: Part-II
archana velapure
2014
View PDFchevron_right
Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors
Urs Sprecher, Michael Hennig, Markus Boehringer
Bioorganic & Medicinal Chemistry Letters, 2010
View PDFchevron_right
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Giovanna Scapin
Bioorganic & Medicinal Chemistry Letters, 2007
View PDFchevron_right
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors
Robert Mathvink
Bioorganic & Medicinal Chemistry Letters, 2005
View PDFchevron_right
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV
stefanie flohr
Bioorganic & Medicinal Chemistry Letters, 2014
View PDFchevron_right
4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Giovanna Scapin
Bioorganic & Medicinal Chemistry Letters, 2007
View PDFchevron_right
(3R)-3-Amino-4-(2,4,5-trifluorophenyl)-N-{4-[6-(2-methoxyethoxy)benzothiazol-2-yl]tetrahydropyran-4-yl}butanamide as a potent dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
TOMINAGA FUKAZAWA
Bioorganic & Medicinal Chemistry Letters, 2008
View PDFchevron_right
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
JUN FENG
Bioorganic & Medicinal Chemistry Letters, 2008
View PDFchevron_right
Design, Synthesis and Biological Evaluation of N 4 -Sulfonamido- Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors
Mahmoud A Al-Sha'er
View PDFchevron_right
Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors
Camilo Rojas
Bioorganic & Medicinal Chemistry Letters, 2004
View PDFchevron_right
1, 3-Disubstituted 4-Aminopiperidines As Useful Tools In the Optimization of the 2-Aminobenzo [a] Quinolizine Dipeptidyl Peptidase IV Inhibitors
Markus Boehringer
Bioorganic & medicinal …, 2007
View PDFchevron_right