Anti-inflammatory effects of exercise training in the skeletal muscle of patients with chronic heart failure (original) (raw)
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Anti-Inflammatory Effects of Exercise Training in the Early Period after Myocardial Infarction
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Inflammation, 2012
The aim of this study is to compare the response of interleukin-6 (IL-6) and soluble tumor necrosis factor alpha receptor 1 (s-TNFr1) to two submaximal intensities of exercise in individuals with heart failure (HF). Thirty-two HF individuals aged 45.53±9.41 years, classes II and III of the New York Heart Association (NYHA) classification underwent two sessions of exercise at low and moderate intensities with blood analysis at baseline, exercise and after exercise. The differences were evaluated by Friedman test and factorial ANOVA. Alpha=5% was considered. No difference in IL-6 was detected for low intensity. At moderate intensity, there was a significant increase after exercise. The s-TNFr1 increased in moderate-intensity exercise and went back to baseline levels after it. A session of moderate-intensity exercise is better than low-intensity exercise at promoting positive immediate inflammatory responses in individuals with HF class II and III of the NYHA.
Medical Laboratory Journal, 2020
Background and objectives: Evidence has shown that inflammatory mediators play an important role in the pathogenesis of atherosclerosis. The aim of this study was to evaluate effects of eight weeks of continuous and intermittent aerobic exercise on some inflammatory indices in men with heart failure. Methods: The effects of continuous aerobic exercise (at 45-70% maximum heart rate) and intermittent aerobic exercise (at 45-80% of maximum heart rate) on the level of interleukin 6 (IL-6) and high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor alpha (TNFα) were evaluated in 42 men with heart failure using commercial ELISA kits. Blood samples were taken after 12 hours of fasting one hour before the first session and 48 hours after the last exercise session. The subjects performed exercises three sessions a week, for eight weeks. Data were analyzed by one-way ANOVA at significance of 0.05. Results: After the exercise program, serum hs-CRP (P=0.023), IL-6 (P=0.018) and TNF-α (P=0.048) differed significantly between the exercise groups and the control group. In addition, serum levels of IL-6 and hs-CRP decreased slightly in the intermittent aerobic group, but there was no significant difference between the two exercise groups. Intermittent aerobic exercise significantly reduced serum TNF-α level compared to the control group. Conclusion: Probably aerobic exercise can have positive effects on the level of hs-CRP, IL-6 and TNF-α in patients with heart failure.
Anti-inflammatory effect of physical training in heart failure: role of TNF-alpha and IL-10
Arquivos brasileiros de cardiologia, 2009
Over the past 50 years, the understanding of the deteriorative changes involved in the progression of heart failure (HF), initially described as resulting from changes in salt and fluid retention, or changes in hemodynamic parameters, have changed significantly. Recently, several studies conducted in HF patients showed altered plasma (or serum) levels of pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), interleukins 1, 6, and 18, and cardiotropin-1, among other inflammatory markers. These changes were independent of HF etiology, suggesting a common pathogenic pathway. In response to these new findings, interventions to prevent and/or reduce these inflammatory changes have been proposed. The aerobic training-induced cardiovascular benefits of physical exercises performed at intensities ranging from mild to moderate have been previously reported. Moreover, it has been shown that moderate aerobic physical training seems to be able to modulate, in the presence...
Cardiology Research and Practice, 2011
Background. We pooled data from four studies, to establish whether exercise training programs were able to modulate systemic cytokine levels of tumour necrosis factor-alpha (TNF-alpha) and interleukin-6 (IL-6). A second aim was to establish if differences in ExT regimens are related to degree of change in cytokines and peak VO2.Methods. Data from four centres relating to training protocol, exercise capacity, and cytokine measures (TNF-alpha and IL-6) were pooled for analysis.Results. Data for 106 CHF patients were collated (98 men, age 62 ± 10 yrs, wt 79 ± 14 Kg). Patients were moderately impaired (peak VO216.9 ± 4.4 mls/kg/min), with moderate LV systolic dysfunction (EF 30 ± 6.9%), 78% (83) had ischaemic cardiomyopathy. After ExT, peak VO2increased 1.4 ± 3.4 ml/kg/min (P<.001), serum TNF-alpha decreased 1.9 ± 8.6 pg/ml (P=.02) and IL-6 was not significantly changed (0.5 ± 5.4 pg/ml,P=.32) for the whole group. Baseline and post-training peak VO2changes were not correlated with ch...
Physical training reduces peripheral markers of inflammation in patients with chronic heart failure
European Heart Journal, 2001
Aims Previous studies have shown an abnormal expression of cellular adhesion molecules and cytokines in chronic heart failure, which may be related to endothelial dysfunction characterizing this syndrome. Our study investigates the effects of physical training on serum activity of some peripheral inflammatory markers associated with endothelial dysfunction, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), macrophage chemoattractant protein-1 (MCP-1), soluble intercellular adhesion molecule-1 (sICAM-1) and soluble vascular cell adhesion molecule-1 (sVCAM-1) in patients with chronic heart failure. Methods and Results Serum levels of GM-CSF, MCP-1, sICAM-1 and sVCAM-1 were determined in 12 patients with stable chronic heart failure (ischaemic heart failure: 6/12, dilated cardiomyopathy: 6/12, New York Heart Association: II-III, ejection fraction: 24 2%) before and after a 12-week programme of physical training in a randomized crossover design. In addition, the functional status of chronic heart failure patients was evaluated by using a cardiorespiratory exercise stress test to measure peak oxygen consumption. Physical training produced a significant reduction in serum GM-CSF (28 2 vs 21 2 pg. ml 1 , P<0•001), MCP-1 (192 5 vs 174 6 pg. ml 1 , P<0•001), sICAM-1 (367 31 vs 314 29 ng. ml 1 , P<0•01) and sVCAM-1 (1247 103 vs 1095 100 ng. ml 1 , P<0•01) as well as a significant increase in peak oxygen consumption (14•6 0•5 vs 16•5 0•5 ml. kg 1 min 1 , P<0•005). A significant correlation was found between the training-induced improvement in peak oxygen consumption and percentage reduction in soluble adhesion molecules sICAM-1 (r= 0•72, P<0•01) and sVCAM-1 (r= 0•67, P<0•02). Conclusion Physical training affects beneficially peripheral inflammatory markers reflecting monocyte/macrophageendothelial cell interaction. Training-induced improvement in exercise tolerance is correlated with the attenuation of the inflammatory process, indicating that inflammation may contribute significantly to the impaired exercise capacity seen in chronic heart failure.
Health & Research Journal
Aim: The present study investigates the effect of Strength Training addition in a High Intensity Interval Training (HIIT) program, on the inflammatory profile of chronic heart failure (CHF) patients. Materials and Methods: Forty-six CHF patients were randomized into the two different exercise rehabilitation groups. A patient group (control) performed HIIT and another group performed Combined (HIIT and strength training) Exercise Training (COM) for a three- month period. Before and after rehabilitation, all patients performed a maximal cardiopulmonary exercise testing (CPET). Microcirculatory parameters were assessed by Near Infrared Spectroscopy; CRP, IL-2, IL-6, IL-10 and VEGF levels were measured in plasma. Results: Cardiopulmonary parameters and microcirculatory indices improved after rehabilitation. CRP and the IL-6/IL-10 ratio decreased after rehabilitation. By linear regression analysis, a negative correlation was noted between IL-2, IL-6 and IL-10 changes (post-CPET values) a...
Journal of the American College of Cardiology, 2002
We sought to investigate the effects of physical training on circulating proinflammatory cytokines and the soluble apoptosis mediators Fas (sFas) and Fas ligand (sFasL) in patients with chronic heart failure (CHF). BACKGROUND Recent investigations have shown an overexpression of circulating proinflammatory cytokines and soluble apoptosis mediators in patients with CHF, which may be related to their exercise intolerance and clinical deterioration. METHODS Plasma levels of tumor necrosis factor-alpha (TNF-alpha), soluble TNF receptors I and II (sTNF-RI and sTNF-RII, respectively), interleukin-6 (IL-6), soluble IL-6 receptor (sIL-6R), sFas and sFasL were measured in 24 patients with stable CHF (New York Heart Association functional class II/III; left ventricular ejection fraction 23.2 Ϯ 1.3%) and in 20 normal control subjects before and after a 12-week program of physical training in a randomized, crossover design. Functional status of patients with CHF was evaluated by using a cardiorespiratory exercise test to measure peak oxygen consumption (VO 2 max). RESULTS Physical training produced a significant reduction in plasma levels of TNF-alpha (7.5 Ϯ 1.0 pg/ml vs. 4.6 Ϯ 0.7 pg/ml, p Ͻ 0.001), sTNF-RI (3.3 Ϯ 0.2 ng/ml vs. 2.7 Ϯ 0.2 ng/ml, p Ͻ 0.005), sTNF-RII (2.6 Ϯ 0.2 ng/ml vs. 2.3 Ϯ 0.2 ng/ml, p ϭ 0.06), IL-6 (8.3 Ϯ 1.2 pg/ml vs. 5.9 Ϯ 0.8 pg/ml, p Ͻ 0.005), sIL-6R (34.0 Ϯ 3.0 ng/ml vs. 29.2 Ϯ 3.0 ng/ml, p Ͻ 0.01), sFas (5.5 Ϯ 0.7 ng/ml vs. 4.5 Ϯ 0.8 ng/ml, p ϭ 0.05) and sFasL (34.9 Ϯ 5.0 pg/ml vs. 25.2 Ϯ 4.0 pg/ml, p Ͻ 0.05), as well as a significant increase in VO 2 max (16.3 Ϯ 0.7 ml/kg per min vs. 18.7 Ϯ 0.8 ml/kg per min, p Ͻ 0.001). Good correlations were found between a training-induced increase in VO 2 max and a training-induced reduction in levels of the proinflammatory cytokine TNF-alpha (r ϭ Ϫ0.54, p Ͻ 0.01) and the apoptosis inducer sFasL (r ϭ Ϫ0.57, p Ͻ 0.005) in patients with CHF. In contrast, no significant difference in circulating cytokines and apoptotic markers was found with physical training in normal subjects. CONCLUSIONS Physical training reduces plasma levels of proinflammatory cytokines and the sFas/sFasL system in patients with CHF. These immunomodulatory effects may be related to the training-induced improvement in functional status of patients with CHF.
2016
License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The cardiovascular autonomic imbalance in patients after myocardial infarction (MI) provides a significant increase in mortality rate, and seems to precede metabolic, hormonal, and immunological changes. Moreover, the reduction in the parasympathetic function has been associated with inflammatory response in different pathological conditions. Over the years, most of the studies have indicated the exercise training (ET) as an important nonpharmacological tool in the management of autonomic dysfunction and reduction in inflammatory profile after a myocardial infarction. In this work, we reviewed the effects of ET on autonomic imbalance after MI, and its consequences, particularly, in the post-MI inflammatory profile. Clinical and experimental evidence regarding relationship between alterations in autonomic regulation and local or systemic inflammation re...