Relationship Between Increased Serum Resistin Level and Severity of Coronary Artery Disease (original) (raw)
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The Association between Serum Resistin Levels and Major Adverse Cardiac Events
World Journal of Cardiovascular Diseases, 2017
Resistin is a member of the family of cysteine-rich secretary proteins called resistin-like molecules (RELMs). It is suggested to be involved in inflammatory conditions and atherosclerosis. We have established a significant correlation between serum resistin levels and coronary artery disease (CAD) in a study was performed between 2011 and 2012 in our institute in two hundred fourteen patients (164 CAD patients and 50 controls). Then the CAD patients were followed up to investigate the relationship between increased serum resistin levels and major adverse cardiac events (MACE) between 2012 and 2016. One hundred fifty-five of 164 patients (95%) were followed up and 9 patients lost to follow up. There were 39 MACE (25%) in four years of follow-up. There were 16 in-hospital deaths due to cardiac causes, 8 revascularization procedures, and 15 re-hospitalization due to acute coronary syndrome (ACS) or heart failure (HF). The patients with MACE had similar serum resistin level (median: 71.37 pg/ml) compared to patients without MACE (median: 80.23 pg/ml) (p > 0.05).
The Association of Resistin with Coronary Disease in the General Population
Journal of Atherosclerosis and Thrombosis, 2014
To explore the association between resistin expression and the incidence of ischemic heart disease in the general population. Methods: A follow-up study of 6636 adults recruited randomly from the general population. Results: The serum resistin concentration was higher in women (6.1 ng/mL; CI95%= 6.0-6.2) than in men (5.6 ng/mL; CI95%= 5.5-5.7). Individuals in the 5th quintile or higher of resistin (RQ5) were younger (P＜0.001) and had a lower prevalence of arterial hypertension (P＜0.001), abdominal obesity (P＜0.001), diabetes (P＜0.001) and dyslipidemia (P＜0.001). The cardiovascular risk estimated by the Framingham function was also lower in the RQ5 subgroup (P＜0.001); however, the prevalence of smoking was higher (P＜0.001), as was the prevalence of low HDL cholesterol (P＜0.001). After 3.5 years of follow-up, the RQ5 subgroup had a higher incidence of acute myocardial infarction (AMI, RR= 1.9; CI95%= 1.01-3.54). In the population without diabetes, the RQ5 subgroup had a higher risk of AMI (RR = 2.4; CI95%= 1.10-5.17), and the risk of AMI was highest in women in this group (4.97; CI95%=1.33-18.57). The risk levels were significant in the Cox models adjusted for age, sex and smoking; and the hazard ratio was 2.5 for AMI (CI95%= 1.29-4.70) in the sample of patients matched by sex and smoking status. Conclusions: Resistin may be a risk marker for ischemic heart disease in the general population. The serum resistin concentration is higher in women, and the associated increase in the risk of AMI based on the resistin level is also higher in women than in men.
Serum resistin: A possible link between inflammation, hypertension and coronary artery disease
Background & Objectives: Inflammation is considered as the main triggering factor in evolution of atherosclerotic pathology of heart and blood vessels. Resistin, an inflammatory cytokine is proved to be a main mediator of initiation and progression of mechanisms leading to atherosclerosis, hypertension and ultimately to coronary artery disease. Our objective was to compare the levels of serum resistin, C-reactive protein and total leucocyte count in subjects of hypertension and coronary artery disease; and to observe the correlation of serum resistin with CRP and TLC in the study participants. Methods: Eighty selected participants were divided into four equal groups including normal healthy participants, newly diagnosed cases of hypertension, stable angina pectoris and myocardial infarction, both with hypertension. The study was conducted in the physiology department of Post Graduate Medical Institute Lahore, during 2013. After consent, history and examination, fasting blood samples of the participants were collected. Serum resistin and C-reactive protein were determined by using standard techniques of enzyme linked immunosorbent assay, while total leukocyte count by automated hematology analyzer. Results: The values of serum resistin, C-reactive protein and total leukocyte count were found significantly raised in patients of hypertension, angina pectoris and myocardial infarction with hypertension as compared to normal participants (p<0.001 for all). Significantly positive correlation of resistin was observed with TLC only in hypertensive patients of myocardial infarction (r = 0.459, n = 20, p = 0.042) while in other study groups correlation between resistin and TLC as well as CRP was non-significant. Conclusion: Serum resistin levels along with CRP and TLC are significantly raised in patients of hypertension and coronary artery disease while resistin levels revealed significantly positive correlation with TLC in hypertensive patients of myocardial infarction.
Comparison between serum resistin levels in patients with myocardial infarction and unstable angina
Background and objectives: Studies on human adipose tissue revealed that this tissue is not only an energy storing, but an endocrine organ that secrets a variety of hormones, cytokines, growth factors, and bioactive compounds, known as adipokines into the circulation that have effects on endocrine, metabolic, and inflammatory processes that take part in the control of energy homeostasis. Resistin is an adipocytokine that has been suggested to link obesity, diabetes, and atherosclerosis. Our objective was to examine the effects of some metabolic variables on the level of serum resistin in patients with acute myocardial infarction, AMI and unstable angina, UA. Also to investigate resistin levels in different demographic characteristics including smoking, gender, hypertension and family history. Method: A case control study was carried out over a period of more than 2 years (Jan 2009 to March 2012). Forty seven patients (25 with AMI and 22 with UA) were collected from the departments of cardiology in both Al-Khademiyia Teaching Hospital and Ibn Al-Nafees Hospital in Baghdad-Iraq. The control consisted of 25 healthy subjects with no history of cardiovascular disease. Serum resistin was measured using DRG Human Resistin ELISA (EIA-4194) Kit, USA for the quantitative determination by ELISA technique (Enzyme linked immunosorbant assay). Serum lipid profile, including total cholesterol, triglyceride (TG), HDL-C and LDL-C, was determined enzymatically using (Biomeueaux, France) kits .Glycosylated haemoglobin, HbA1c % was measured by colorimetric method at 415 nm using Stanbio kit, procedure No. P350. Results: A highly significant difference existed in serum resistin levels between the AMI and the UA patients as compared to their controls, and a significant difference between the two groups when compared to each other. No significant differences was found between serum resistin, lipid profile, fasting serum glucose , HbA1c and body mass index in both AMI and UA groups when they were classified according to their demographic characteristics. As concerning the relation with other metabolic variables measured serum resistin of hypertensive UA patients only showed a significant correlation with their serum total cholesterol , LDL-C and their atherogenic index (p<0.001). Conclusion: according to the study results and patients demographic characteristics, it can concluded that level of serum resistin is raised significantly in AMI and UA and may be affected by some metabolic variables independent of the demographic characteristics like smoking habits , hypertension and family history.
The association of resistin with cardiovascular disease in the Multi-Ethnic Study of Atherosclerosis
Atherosclerosis, 2015
To describe the relationship between circulating resistin levels and cardiovascular diseases (CVD) and all-cause death in a multi-ethnic cohort. We studied 1913 participants from the Multi-Ethnic Study of Atherosclerosis with measurements of plasma resistin levels. Absolute proportions experiencing new-onset atrial fibrillation (AF), atherosclerotic CVD (myocardial infarction, angina, resuscitated cardiac arrest, stroke), heart failure (HF), and all-cause death were calculated for each quartile of resistin. We used adjusted Cox proportional regression modeling resistin as a continuous variable per standard deviation of log-transformed resistin and secondarily as a categorical variable using resistin quartiles. Results were stratified by sex and race/ethnicity. The mean age of the population was 64.5 ± 10 years with half being female and a median resistin concentration of 15.1 ng/mL (11.9-19.1). Mean follow-up time was 7.2 ± 1.8 years. There was a graded increase in the occurrence of...
2010
Introduction: Recent studies have demonstrated that resistin, an inflammatory adipokine, plays a key role in the pathogenesis of coronary artery disease (CAD). It is also known that the resistin gene (RETN) polymorphism, particularly in promoter region, is correlated with serum resistin levels and consequently an increased risk of CAD. This study investigates potential correlation between resistin gene polymorphism at-420C/G (rs1862513) and diabetes, as well as severity of CAD, in an Iranian cohort. Methods: As a cross-sectional study, we recruited 113 subjects who were candidate for diagnostic coronary angiography. Laboratory measurements were FBS, OGTT, HbA1C, hsCRP, and lipid profile. Genotyping for Single Nucleotide Polymorphism (SNP) was performed using the PCR-RFLP method. Results: Our findings showed that CAD patients with diabetes had significantly higher FBS, HbA 1 C and cholesterol levels and more severe coronary artery stenosis compared to non-diabetic subjects. Besides, the frequencies of the RETN-420C/G genotype in the diabetic group were significantly higher as compared to those in non-diabetic group (P=0.009). Moreover, the CC genotype carriers had more than twofold increased risk of Type 2 diabetes mellitus (T2DM) compared with the GG carriers. Although, there was no statistically significant correlation between RETN-420C/G polymorphism and severity of CAD (P=0.3), when we reanalyzed data with entering both the patients with one and two involved coronary arteries as one group, it was observed that patients with CC genotype more severely suffered from the coronary artery disease than the other genotypes (P=0.04). The Odds Ratio (OR) and relative risk for CAD patients with CC genotype were 4.33 (95%CI=1.02-18.38) and 2.25 (95%CI=0.97-5.19, P= 0.04), respectively. Conclusion: The results indicate that polymorphism in promoter region of RETN gene plays a role in the pathogenesis of coronary artery disease (probably due to its inflammatory characteristics) and the CC genotype is associated with an increased risk of diabetes and CAD compared to GG and CG.
Resistin and Cardiovascular Disease
Trends in Cardiovascular Medicine, 2011
Different studies have suggested the involvement of resistin in the pathogenesis of cardiovascular diseases, including hypertension, coronary artery disease, heart failure and cerebrovascular disease. Different articles were retrieved by searching the following databases: PubMed, Embase, Ovid Medline. Based on our results, we conclude that serum resistin concentration is involved in the pathogenesis of arteriosclerosis. In addition, serum resistin levels are increased in patients with hypertension, coronary heart disease and cerebrovascular disease, and are related to the development and worsening of heart failure.
Prognostic value of serum resistin levels in patients with acute myocardial infarction
Kardiologia Polska, 2014
Background: Resistin is a novel adipokine that is suggested to be involved in inflammatory conditions and atherosclerosis. Aim: To investigate the prognostic importance of resistin in acute myocardial infarction (AMI) patients. Methods: Resistin levels were measured in a population of 132 patients with AMI, of whom 72 (54%) had a diagnosis of ST elevation myocardial infarction (STEMI), and 60 (46%) had non-ST elevation myocardial infarction (NSTEMI). Thirty-three consecutive subjects who were referred to elective coronary angiography due to chest pain evaluation with normal coronary angiograms served as controls. All patients were followed-up for the occurrence of major adverse cardiac events (MACE). Results: There was a significant increase in serum resistin levels in patients with AMI compared to controls (3.71 ± 4.20 vs. 2.00 ± 1.05, p = 0.001, respectively). However, serum resistin levels were similar in patients with STEMI and NSTEMI. (4.26 ± 5.11 vs. 3.06 ± 2.64, p = 0.49, respectively). The patients with MACE had significantly higher levels of serum resistin levels compared to either the AMI or the control group (6.35 ± 5.47, p = 0.005, respectively). Logistic regression analysis revealed that resistin, left ventricular ejection fraction, and coronary artery bypass graft were independent predictors of MACE in AMI patients (OR = 1.11, 95% CI 1.01-1.22, p = 0.03 and OR = 3.84, 95% CI 1.26-11.71, p = 0.018, respectively). Conclusions: Serum resistin level was increased in patients with AMI and constituted a risk factor for MACE in this group.