Native valve endocarditis due to coagulase-negative staphylococciClinical and microbiologic features (original) (raw)
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Native valve endocarditis due to coagulase-negative staphylococci
The American Journal of Medicine, 1987
Using a large cohort of patients from the International Collaboration on Endocarditis Merged Database, we compared coagulase-negative staphylococcal (CoNS) native-valve endocarditis (NVE) to NVE caused by more common pathogens. Rates of heart failure and mortality were similar between patients with CoNS NVE and patients with Staphylococcus aureus NVE, but rates for both groups were significantly higher than rates for patients with NVE due to viridans streptococci. These results emphasize the importance of CoNS as a cause of NVE and the potential for serious complications with this infection. Coagulase-negative staphylococci (CoNS) accounts for ∼5% of all episodes of native-valve endocarditis (NVE) [1-3]. Rates of CoNS bacteremia [4, 5] and CoNS endocarditis [6] have increased, underscoring the need to improve our knowledge of this pathogen. Although prior case reports and retrospective series [6-9] have suggested high rates of complications among patients with NVE due to CoNS, our understanding of this
Heart, 1990
Native valve endocarditis caused by coagulase negative staphylococci has become more comiton. A study of 35 cases showed that the infections were usually acquired in the community and occurred in men (mean age 51 years). A pre-existing cardiac abnormality (mitral leaflet prolapse in a third of patients) was detected in 26 (74%). The source of the organisms in the community acquired infections was assumed to be the skin, though lesions were seldom demonstrated; most hospital acquired infections resulted from intravenous devices. Community acquired organisms were usually sensitive to penicillin, whereas those acquired in hospital were often multiresistant. Most infections were caused by Staphylococcus epidermidis. The frequency of acute presentation (26%) and of major neurological abnormality (23%), together with the need for valve replacement (often emergency) (51%) and the mortality (36%) suggest that coagulase negative staphylococci can be virulent aggressive pathogens, mimicking Staphylococcus aureus.
Revista española de cardiología, 2005
Coagulase-negative staphylococci are the most frequently isolated microorganisms in early prosthetic valve endocarditis. However, they rarely cause endocarditis in native valves. The profile of patients with left-sided native valve endocarditis by coagulase-negative staphylococci is unknown, because available data are scarce and outdated. We analyzed the epidemiological, clinical, radiographic, microbiological, and echocardiographic features and clinical course in 17 patients with this entity out of a total of 441 consecutive patients diagnosed as having endocarditis. The results show that left-sided native valve endocarditis caused by coagulase-negative staphylococci is more common than previously reported, can cause heart failure due to valvular involvement, often needs surgery, and is associated with high mortality.
Heart, 2008
Endocarditis: prospective cohort study on the International Collaboration on valve endocarditis a contemporary update based Coagulase-negative staphylococcal prosthetic http://heart.bmj.com/cgi/content/full/95/7/570 Updated information and services can be found at: These include: References http://heart.bmj.com/cgi/content/full/95/7/570#BIBL ABSTRACT Objective: To describe the contemporary features of coagulase-negative staphylococcal (CoNS) prosthetic valve endocarditis (PVE). Design: Observational study of prospectively collected data from a multinational cohort of patients with infective endocarditis. Patients with CoNS PVE were compared to patients with Staphylococcus aureus and viridans streptococcal (VGS) PVE. Setting: The International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) is a contemporary cohort of patients with infective endocarditis from 61 centres in 28 countries. Patients: Adult patients in the ICE-PCS with definite PVE and no history of injecting drug use from June 2000 to August 2005 were included. Interventions: None. Main outcome measures: Heart failure, intracardiac abscess, death.
WMJ : official publication of the State Medical Society of Wisconsin, 2002
The incidence of infective endocarditis (IE) is thought to be around 4/100,000 person years in the general population, and 15/100,000 over the age of 50 years. The risk of acquiring IE is higher among patients with valvular heart disease (e.g., rheumatic valves, bicuspid aortic valves, myxomatous degeneration, etc.), congenital heart disease (e.g., coarctation, patent ductus arteriosus, ventricular septal defect, etc.), prosthetic cardiac valves, and among intravenous drug abusers. Staphylococcus aureus is one of the most common infective agents of IE, and most commonly originates from nosocomial sources, e.g., intravenous and arterial catheters, pacemaker leads, and prosthetic valves. Endocarditis caused by S aureus has a mortality rate of approximately 20% to 40%. In up to 40% of patients, IE caused by S aureus is associated with embolic complications. The risk of death increases with the development of complications. The epidemiology and microbiology of S aureus are changing rapi...
Infective Endocarditis Due to Staphylococcus aureus
Archives of Internal Medicine, 1999
Background: The use of anticoagulant therapy in patients with infective endocarditis (IE) is a controversial issue. Objective: To study the impact of anticoagulant therapy on the clinical outcome, mortality, and cause of death in a series of patients with native and prosthetic leftsided Staphylococcus aureus IE. Methods: This report is based on all consecutive cases of IE diagnosed at our hospital between 1975 to 1997. Clinical data, including the use of anticoagulant therapy at the time of diagnosis, were prospectively obtained, and antibiotic treatment and surgical indications were uniform throughout the study period. Computed tomographic scans of all clinical records were reviewed. Results: Of 637 consecutive patients with IE, 56 had leftsided S aureus IE affecting native valves in 35 patients and prosthetic valves in 21 patients. Of the patients with prosthetic valve IE, 19 (90%) were taking oral antico