Nucleic Acid Complexing Glycosyl Nucleoside-Based Amphiphile (original) (raw)

Bioconjugate Chemistry, 2005

Abstract

A neutral amphiphile derived from uridine featuring two oleyl chains and one glucose for DNA binding was prepared using a convenient four-step synthetic route. The nucleic acid binding capabilities of this amphiphile were investigated by UV-vis, quasi-elastic light scattering (QELS), transmission electronic microscopy (TEM), gel electrophoresis, 31P NMR, IR, and circular dichroism (CD). Amphiphile-nucleic acid complex formation is a consequence of the amphiphilic character of the molecule, phosphate-sugar, and nucleobase-nucleobase interactions. This work presents for the first time a glyco-nucleo-amphiphile capable of binding efficiently the nucleic acid double helix structure.

Philippe Barthélémy hasn't uploaded this paper.

Let Philippe know you want this paper to be uploaded.

Ask for this paper to be uploaded.