Piperidinylpyrroles: Design, synthesis and binding properties of novel and selective dopamine D4 receptor ligands (original) (raw)
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors
Paul D Leeson
Bioorganic & Medicinal Chemistry Letters, 1999
View PDFchevron_right
Synthesis of novel 2-(piperazino-1-yl-alkyl)-1H-benzimidazole derivates and assessment of their interactions with the D 2 dopamine receptor
Vladimir B. Šukalović, Journal of the Serbian Chemical Society
Journal of the Serbian Chemical Society, 2019
View PDFchevron_right
Substituted pyrazoles as novel selective ligands for the human dopamine D4 receptor
Paul D Leeson
Bioorganic & Medicinal Chemistry, 1998
View PDFchevron_right
Synthesis, dopamine D 2 receptor binding studies and docking analysis of 5-[3-(4-arylpiperazin-1-yl)propyl]-1 H-benzimidazole, 5-[2-(4-arylpiperazin-1-yl)ethoxy]-1 H-benzimidazole and their analogs
Goran Roglic
European Journal of Medicinal Chemistry, 2005
View PDFchevron_right
Synthesis and characterization of selective dopamine D2 receptor ligands using aripiprazole as the lead compound
Robert Mach
Bioorganic Medicinal Chemistry, 2011
View PDFchevron_right
Azaindole derivatives with high affinity for the dopamine D4 receptor: Synthesis, ligand binding studies and comparison of molecular electrostatic potential maps
Harald Hübner
Bioorganic & Medicinal Chemistry Letters, 1999
View PDFchevron_right
1,2,4-Triazolyl Octahydropyrrolo[2,3‐b]pyrroles: A New Series of Potent and Selective Dopamine D3 Receptor Antagonists
Andrea Kuan Cie Wong
Bioorganic & Medicinal Chemistry, 2016
View PDFchevron_right
Synthesis of novel piperazino-alkyl-1H-benzo[d]imidazole derivates and assessment of their interactions with the D2 dopamine receptor
Jelena Penjišević
Journal of the Serbian Chemical Society, 2018
View PDFchevron_right
Novel benzopyrano[3,4-c]pyrrole derivatives as potent and selective dopamine D3 receptor antagonists
Adrian Newman-Tancredi
Bioorganic & Medicinal Chemistry Letters, 1999
View PDFchevron_right
Synthesis and characterization of selective dopamine D2 receptor antagonists. 2. Azaindole, benzofuran, and benzothiophene analogs of L-741,626
Robert Mach, Jinbin Xu
Bioorganic & Medicinal Chemistry, 2010
View PDFchevron_right
Pyrrolo[1,3]benzothiazepine-Based Serotonin and Dopamine Receptor Antagonists. Molecular Modeling, Further Structure−Activity Relationship Studies, and Identification of Novel Atypical Antipsychotic Agents
maria assunta di cesare
Journal of Medicinal Chemistry, 2004
View PDFchevron_right
Synthesis of 2-(5-Bromo-2,3-dimethoxyphenyl)-5-(aminomethyl)-1 H-pyrrole analogues and their binding affinities for dopamine D 2, D 3, and D 4 receptors
Yunsheng Huang
Bioorganic & Medicinal Chemistry, 2003
View PDFchevron_right
Synthesis, Molecular Properties Estimations, and Dual Dopamine D2 and D3 Receptor Activities of Benzothiazole-Based Ligands
Holger Stark
Frontiers in Chemistry
View PDFchevron_right
Certain 1,4-Disubstituted Aromatic Piperidines and Piperazines with Extreme Selectivity for the Dopamine D4 Receptor Interact with a Common Receptor Microdomain
Harel Weinstein
Molecular Pharmacology, 2004
View PDFchevron_right
Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors
Vukic Soskic
European Journal of Medicinal Chemistry, 2008
View PDFchevron_right
2-{4-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkoxy]phenyl}-2 H -benzotr iazoles and their N-Oxides as Ligands for some 5-Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes
Fabio Sparatore
Pharmacy and Pharmacology Communications, 2000
View PDFchevron_right
Synthesis and biological investigations of dopaminergic partial agonists preferentially recognizing the D4 receptor subtype
Harald Hübner
Bioorganic & Medicinal Chemistry Letters, 2006
View PDFchevron_right
2-{4-[ω-[4-(2-Methoxyphenyl)-1-piperazinyl]alkoxy]phenyl}-2H-benzotr iazoles and their N-Oxides as Ligands for some 5-Hydroxytryptamine, Dopamine and Adrenergic Receptor Subtypes
Fabio Sparatore
Pharmacy and Pharmacology Communications, 2000
View PDFchevron_right
Di- and trisubstituted pyrazolo[1,5-a]pyridine derivatives: synthesis, dopamine receptor binding and ligand efficacy
Harald Hübner, Tarek Aboul-fadl
Bioorganic & Medicinal Chemistry Letters, 2002
View PDFchevron_right
Introduction of a methyl group in α- or β-position of 1-heteroarylethyl-4-phenyl-piperazines affects their dopaminergic/serotonergic properties
Goran Roglic
Archiv Der Pharmazie, 2001
View PDFchevron_right
N-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butyl, butenyl and butynyl}arylcarboxamides as novel dopamine D3 receptor antagonists
Christina bennett
Bioorganic & Medicinal Chemistry Letters, 2003
View PDFchevron_right
Functionally Selective Dopamine D 2 /D 3 Receptor Agonists Comprising an Enyne Moiety
Peter Gmeiner
Journal of Medicinal Chemistry, 2013
View PDFchevron_right
Synthesis and biological evaluation of 3-{[4-(4-[ 18 F]fluorophenyl)methyl] piperazin-1-yl}-methyl-1H-pyrrolo[2,3-b]pyridine for in vivo studies of dopamine D 4 receptor
Wei Zhou
Journal of Radioanalytical and Nuclear Chemistry, 2004
View PDFchevron_right
Searching for multi-target antipsychotics: Discovery of orally active heterocyclic N-phenylpiperazine ligands of D2-like and 5-HT1A receptors
Gilda Neves
Bioorganic & Medicinal …, 2010
View PDFchevron_right
Novel Heterocyclic Trans Olefin Analogues of N-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butyl}arylcarboxamides as Selective Probes with High Affinity for the Dopamine D3 Receptor
Christina bennett
Journal of Medicinal Chemistry, 2005
View PDFchevron_right
6-[2-(4-arylpiperazin-1-yl)ethyl]-4-halo-1,3-dihydro-2h-benzimidazole-2-thiones: Synthesis and pharmacological evaluation
Goran Roglic
Journal of The Serbian Chemical Society, 2007
View PDFchevron_right