High-Throughput 1 H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library (original) (raw)

High-Throughput 1 H NMR and HPLC Characterization of a 96-Member Substituted Methylene Malonamic Acid Library

Journal of Combinatorial Chemistry, 1999

Abstract

A solid phase organic synthesis method has been developed for the preparation of substituted methylene malonamic acids and malonic ester mono acids 5. Two substituents are introduced into the core molecule 5 by preparation of unsymmetrical malonic acid ...

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