Striatal binding of the PET ligand11C-raclopride is altered by drugs that modify synaptic dopamine levels (original) (raw)

Bilateral decreases in striatal %-raclopride binding were observed in adult female baboons with high resolution PET following administration of drugs that act centrally on dopaminergic neurons. At baseline and following administration of d-amphetamine (a dopamine-releasing drug), GBR-12909 (a potent dopamine reuptake inhibitor), or tetrabenazine (a biogenic amine depleting drug) PET scans of %-raclopride binding were obtained in a CTI 931 positron tomograph. In all studies, the ratio of the distribution volumes for the striatum to the cerebellum for llC-raclopride binding decreased significantly by a n average of 16.2% for d-amphetamine, 22.1% for GBR-12909, and 28.3% for tetrabenazine while there were no significant changes observed in the cerebellum or in the rate of systemic metabolism of the radiotracer. These decreases exceed the testhetest variability of striatal 'lC-raclopride binding measured in the same animals under identical experimental conditions . Together these studies demonstrate that PET measurements of striatal llC-raclopride binding can be used to indirectly and non-invasively monitor changes in synaptic dopamine concentrations that result from a variety of neurophysiologic mechanisms. o 1993 Wiley-Liss, Inc ~~~