Baseline characteristics in the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with Type 2 diabetes (original) (raw)

Abstract

Aim To describe baseline characteristics of patients in the Collaborative AtoRvastatin Diabetes Study (CARDS), a randomized, placebo-controlled trial of lipid lowering with atorvastatin 10 mg daily for the primary prevention of major cardiovascular events in patients with Type 2 diabetes.

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References (20)

  1. Appendix: clinical centres and investigators Aberdeen Royal: J. Broom; Studholme Medical Centre, Ash- ford: S. Butt, K. Tang; The Surgery, Ayr: B. Lennox; Ayr Hos- pital: A. Collier; Beehive Surgery, Bath: J. Hampton; Oldfield Surgery, Bath: T. J. Harris; Pulteney Street Surgery, Bath: P. J. Tilley; Royal United, Bath: J. Reckless; St Chad's Surgery, Bath: E. J. Widdowson; St James' Surgery, Bath: I. M. Orpen; Belfast City: J. R. Hayes, M. Fetherstone; Royal Victoria, Bel- fast: R. McCance; Medical Centre, Chelmsley Wood, Birming- ham: D. M. Allin; Birmingham Heartlands: P. Dodson; Queen Elizabeth, Birmingham: U. Martin; Synexus Limited, Birming- ham: M. Salman; Bolton Diabetes Centre: J. Dean; Bottreaux Practice, Boscastle: G. D. Garrod, C. Jarvis; Royal Bourne- mouth: D. Kerr; St Alban's Medical Centre, Bournemouth: I. Nelemans; Health Centre, Bradford on Avon: J. S. Heffer;
  2. Frenchay, Bristol: V. J. Parfitt; Addenbrookes, Cambridge: M. J. Brown; Synexus Limited, Cardiff: C. Godfrey, G. Newcombe;
  3. St Helier, Carshalton: J. Barron; Aspire Research Limited, Chesterfield: M. Blagden; Rowden Surgery, Chippenham: R. M. C. Gaunt; Porch Surgery, Corsham: A. Cowie; Coventry & Warwickshire: E. Hillhouse; Bridge Medical Centre, Crawley: A. L. Cooper; Pound Hill Surgery, Crawley: N. W. Jackson; Derby City: R. Donnelly, A. R. Scott; Dewsbury District: T. Kemp, C. Rajeswaren; St James', Dublin: J. Nolan; Dumfries & Galloway Royal: J. R. Lawrence; St Michael's, Dun Laoghaire: M. J. McKenna; Muirhead Medical Centre, Dun- dee: B. Kilgallon; Ninewells, Dundee: G. P. Leese, A. D. Mor- ris;
  4. Hairmyres, East Kilbride: S. J. Benbow, D. Mathews;
  5. Edinburgh Royal: V. McAuley, J. D. Walker; Western Gen- eral, Edinburgh: J. A. McKnight; St Margaret's, Epping: G. B. Ambepitiya; Epsom District: C. Speirs; Health Centre, Fal- mouth: A. Rotheray, A. Seaman, V. L. Wight; River Practice, Fowey: A. Middleton; Frome Medical Practice: T. E. Cahill;
  6. Queen Elizabeth, Gateshead: A. Syed, J. Weaver; Medway Maritime, Gillingham: I. Scobie; Gartnaval General, Glasgow: M. Small; Glasgow Royal: J. Gray, K. R. Paterson; Southern General, Glasgow: L. Fraser, S. J. Gallacher; Victoria Infir- mary, Glasgow: C. M. Kesson; Harrogate District: P. Ham- mond; Hartlepool General: G. Hawthorne, J. MacLeod; St Thomas Surgery, Haverfordwest: R. W. G. Thompson; With- ybush General, Haverfordwest: N. Jowett; Princess Royal, Haywards Heath: T. Wheatley; Hemel Hempstead General: C. Johnston; Hetton le Hole Medical Centre: M. Baldasera, P. A. Dobson; Hildenborough Medical Group: P. Goozee; Raigmore, Inverness: S. MacRury; Townhead Surgery, Irvine: M. F. Doig, D. D. McKeith; Leicester General: A. C. Burden, R. Gregory; Synexus Limited, Liverpool: J. Robinson; Royal Liverpool & Broadgreen: J. P. Vora; St John's at Howden, Livingstone: R. S. Gray; Charing Cross, London: C. Leroux, M. Seed; Ham- mersmith, London: A. Dornhorst; North Middlesex, London: H. Tindall; Royal Free, London: M. Press; Symons Medical Centre, Maidenhead: R. C. F. Symons; Hope, Manchester: R. Young; North Manchester Diabetes Centre: P. Wiles; Syn- exus Limited, Manchester: D. Dev, J. James; Trafford General, Manchester: W. P. Stephens; Giffords Primary Care Centre, Melksham: C. H. Lennon; Newcastle General: S. Marshall, M. W. Stewart; Friarage, Northallerton: R. Fisken, A. Waise; Queens Medical Centre, Nottingham: P. I. Mansell; George Eliot, Nuneaton: V. Patel; Southport & Ormskirk, Ormskirk: J. Horsley, R. S. Oelbaum; Royal Oldham: D. Bhatnagar;
  7. Churchill, Oxford: D. Matthews; Royal Alexandra, Paisley: B. M. Fisher, J. Hinnie; Alverton Practice, Penzance: J. F. Ryan; Cape Cornwall Surgery, St. Just, Penzance: A. Ellery; Knowle House Surgery, Plymouth: K. Gillespie, T. Hall; Woolwell Medical Centre, Plymouth: C. P. Fletcher; Pontefract General: J. Howell, C. White; Royal Glamorgan, Pontypridd: M. D. Page;
  8. Queen Alexandra, Portsmouth: K. M. Shaw; Synexus Limited, Reading: M. Horne, M. Thomson; St Cross, Rugby: J. P. O'Hare; The Surgery, Ryde: E. J. Hughes; Brannel Surgery, St Austell: J. R. Cecil; Salisbury District: N. O'Connell; Saltash Health Centre: R. C. Cook; Scunthorpe General: S. Beer; Carter- knowle & Dore Medical Practice, Sheffield: B. King; Norwood Medical Centre, Sheffield: P. Hardy; Southey Green Medical Centre, Sheffield: N. H. Patel; Royal Shrewsbury: A. Mac- Leod;
  9. Chiltern International Limited, Slough: M. Mac- Mahon, P. Palmer; Brook Lane Surgery, Southampton: T. M. Tayler; Royal South Hants, Southampton: B. Leatherdale; Queensway Surgery, Southend on Sea: D. Sills; Lister, Steve- nage: L. J. Borthwick; Royal, Stirling: C. J. G. Kelly, S. B. M. Reith; Huthwaite Medical Centre, Sutton-in-Ashfield: P. Smith, E. Ulliott; John Pease Diabetes Centre, Sutton-in- Ashfield: R. Lloyd-Mostyn, K. Sands; Cwmfelin Medical Centre, Swansea: P. J. Davies; St Helens Medical Centre, Swansea: P. Cummings; Talybont Surgery, Swansea: M. Ferry (deceased), A. H. Jones; Jubilee Surgery, Titchfield: P. W. G. Evans; Brad- ford Road Medical Centre, Trowbridge: S. C. W. Rowlands; Lovemead Group Practice, Trowbridge: M. J. B. Duckworth; Treliske, Truro: S. Fleming; Grosvenor Medical Centre, Tun- bridge Wells: G. J. Charlwood; Pinderfields General, Wake- field: W. Burr, D. Nagi; The Avenue Surgery, Warminster: K. R. Bullen; Watford General: M. Clements; Sandwell District General, West Bromwich: D. A. Robertson; Eastleigh Surgery, Westbury: R. Edwards; Weston-super-Mare General: C. Dayan; Queen Elizabeth II, Welwyn Garden City: P. Wino- cour;
  10. Synexus Limited, Wigan: J. Fraser; Wishaw General: I. A. D. O'Brien; New Cross, Wolverhampton: B. M. Singh; Nottinghamshire Research Associates, Worksop: J. A. Fulton, L. Millar, S. Warner; Maelor, Wrexham: J. N. Harvey; York District: P. Jennings, J. Thow. References
  11. Colhoun HM, Thomason MJ, Mackness MI, Maton SM, Betteridge DJ, Durrington PN et al. Design of the Collaborative AtoRvastatin Diabetes Study (CARDS) in patients with type 2 diabetes. Diabet Med 2002; 19 : 201-211.
  12. Mackness MI, Durrington PN. Lipoprotein separation and analysis for clinical studies. Converse CA, Skinner ER, eds. Lipoprotein Analysis. A Practical Approach . Oxford: Oxford University Press, 1992: 1-42.
  13. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concen- tration of low density lipoprotein in cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem 1972; 18 : 499 -502.
  14. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol lowering with simvastatin in 20 536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360 : 7-22.
  15. Sever PS, Dahlof B, Poulter NR, Wedel H, Beevers G, Caulfield M et al. Prevention of coronary and stroke events with atorvastatin in hypertensive patients who have average or lower-than-average cholesterol concentrations, in the Anglo-Scandinavian Cardiac Outcomes Trial-Lipid Lowering Arm (ASCOT-LLA): a multicentre randomised controlled trial. Lancet 2003; 361 : 1149 -1158.
  16. The Diabetes Control and Complications Trial Research Group. The effect of intensive treatment of diabetes on the development and pro- gression of long-term complications in insulin-dependent diabetes mellitus. N Engl J Med 1993; 329 : 977-986.
  17. UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. Br Med J 1998; 317 : 703 -713.
  18. Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebo-controlled trial. Lancet 2003; 361 : 2005 -16.
  19. Fried LF, Orchard TJ, Kasiske BL. Effect of lipid reduction on the pro- gression of renal disease: a meta-analysis. Kidney Int 2001; 59 : 260 -269.
  20. Levey AS, Bosch JP, Lewis JB, Greene T, Rogers N, Roth D. A more accurate method to estimate glomerular filtration rate from serum creatinine: a new prediction equation. Modification of Diet in Renal Disease Study Group. Ann Intern Med 1999; 130 : 461-470.