Granulomatous Inflammatory Reaction in Breast Silicone Implants (original) (raw)
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Granulomatous dermatitis related to silicone implant
Dermatology online journal, 2013
Silicone in liquid and gel implantation may induce granuloma formation and migration. Although there are many complications associated with solid silicone implantation, there have been no published reports of distant granuloma formation. We present a case of a woman with clinical and serologic findings that are consistent with systemic lupus erythematosus and a histopathologic diagnosis of foreign body granulomatous dermatitis 20 years after solid silicone nasal implantation. We review the literature on silicone granulomas and their treatment and speculate on the potential etiologies of a challenging case presentation.
Granuloma of Silicone Breast Implants A case report and literature review
Revista de Chimie
Silicone, a synthetic polymer containing the element silicon, has been used for breast implants. Complications resulting from the placement of silicone breast implants are becoming more frequent in clinical practice. Breast implant rupture is common and poses challenges for radiologists and physicians. Radiologists must be familiar with the normal and abnormal findings of common implants. Clinically apparent silicone granulomas are a relatively rare complication of breast implant placement and surgical resection is indicated when they are symptomatic or of diagnostic concern. The objective of this study is to examine the latest generations of silicone breast implants and the clinical literature related to silicone granulomas together with a case of silicon granuloma diagnosed in our service. The findings are based on diagnostic breast Ultrasound and MRI scans performed at our service.
Systemic Inflammatory Reaction After Silicone Breast Implant
Aesthetic Plastic Surgery, 2011
Background Systemic inflammation after augmentation mammaplasty with modern silicone implants is not currently recognized. In a prospective controlled study, C-reactive protein and other variables were monitored, aiming to test this hypothesis in a young cohort of patients. Methods Females (18-30 years old, BMI = 18.5-30 kg/m 2 , N = 52) were consecutively recruited for breast implant (n = 24, Group I) and for abdominal liposuction (n = 28, Group II/Controls). Patients were interviewed at baseline and followed until 6 months after operation. Variables included demographic and clinical information, surgical outcome, inflammatory markers and autoantibodies. Results Operations were well tolerated, without surgical or infectious complications. Mean prosthesis size was 258 ± 21 ml (range = 220-280) and mean aspirate of liposuction was 1972 ± 499 ml (range = 1200-3000). Preoperative, 2-month, and 6-month C-reactive protein concentrations for breast implant patients were 1.3 ± 1.2,
Women with silicone breast implants and unexplained systemic symptoms: a descriptive cohort study
The Netherlands journal of medicine, 2013
Since their introduction, the safety of silicone breast implants has been under debate. Although an association with systemic diseases was never established, women continuously blamed implants for their unexplained systemic symptoms. In 2011, a pattern of symptoms caused by systemic reactions to adjuvants (e.g. vaccines, silicone) was identified: 'autoimmune syndrome induced by adjuvants' (ASIA). Our aim was to collect a cohort of women with silicone breast implants and unexplained systemic symptoms to identify a possible pattern and compare this with ASIA. Women with silicone breast implants and unexplained systemic symptoms were invited through national media to visit a special outpatient clinic in Amsterdam. All were examined by experienced consultant physicians and interviewed. Chest X-ray and laboratory tests were performed. Between March 2012 and 2013, 80 women were included, of which 75% reported pre-existent allergies. After a symptom-free period of years, a pattern ...
Clinical Rheumatology, 2000
This cohort study evaluates the postoperative prevalence of antinuclear antibodies (ANA) in relation to symptoms related to the so-called silicone-related symptom complex (SRSC). A total of 63 women who underwent mastectomy followed by immediate breast reconstruction with a silicone implant (SBI) between Septembber 1990 and May 1995 at the University Hospital Rotterdam/Daniel den Hoed Cancer Center, participated voluntarily in the study. Their sera were tested for the presence of antinuclear antibodies (ANA) and at the same time they were screened for the prevalence of SRSC-related symptoms by questionnaire. All patients were also examined physically. Sixteen per cent of the women were ANA positive. There was no difference in SRSC expression between ANA-positive and ANA-negative women. The lack of difference in symptom expression between the ANA-positive and ANA-negative women and the rather low complaint percentage proves that if ANA positivity is related to the SRSC, we found no evidence that patients with a SBI with a positive ANA differed from the ANA-negative patients.
European Journal of Inflammation, 2012
Silicone-gel breast implants (SBI) have been widely used for breast augmentation. Although silicone is generally considered an inert substance, there has been much debate recently on its role in inducing chronic inflammation and systemic connective tissue diseases. The case of a young woman affected by Raynaud's Phenomenon (RP), worsening of vitiligo and of autoimmune thyroiditis following SBI is reported in this paper. Removal of SBI led to temporary RP remission; however, despite notable clinical improvement, nailfold capillary microscopy showed progressive microcirculatory abnormalitles consistent with a diagnosis of early scleroderma. Follow-up of the patient led to the diagnosis of Systemic Sclerosis (SSe) with pulmonary hypertension, The development of SSe after SBI is described, a condition that falls into the recently recognized "ASIA" (Autoimmune/inflammatory Syndrome Induced by Adjuvants) syndrome, Nailfold capillary microscopy is a valuable tool in early SSc diagnosis, in monitoring disease activity and in establishing the risk of an aggressive course of connective tissue disease following silicone breast implantation. The I'elationship between silicone and the immune system requires further reports and investigation in order to determine the main individuill risk factors predisposing to the wide spectrum of adjuvant-induced responses.
Hepatic Silicone Granulomas Secondary to Ruptured Breast Implants: A Report of Two Cases
Case Reports in Hepatology
The differential diagnosis of hepatic granulomas is vast and includes infections, drugs, immunologic diseases, foreign material exposure, and neoplasia. Silicone, whether directly injected into tissues or used as a filler in breast implants, is known to cause localized granulomatous reactions. It can also migrate to other anatomic locations resulting in granulomatous inflammation at a distance. We report two cases of unsuspected hepatic silicone granulomas in patients undergoing liver biopsy for isolated elevated alkaline phosphatase levels, both with a history of ruptured breast implants. These cases highlight the need for awareness of hepatic silicone granulomas as an etiology of elevated liver enzymes in patients with a history of surgical interventions utilizing silica, such as cosmetic surgery.