Clonazepam Augmentation Of Paroxetine In The Treatment Of Panic Disorder: A One Year Naturalistic Follow-Up Study (original) (raw)

Abstract

Background: Recent studies have examined the proper role of benzodiazepine pharmacotherapy in the treatment of Panic Disorder (PD). The purpose of this naturalistic outcome study is to evaluate the possible clinical benefits and safety of paroxetine/ clonazepam combination therapy in the acute treatment phase (weeks 1-16) of PD. We also compare the treatment outcome of paroxetine plus short-term clonazepam versus paroxetine monotherapy at one year follow-up. Method: Seventy-seven patients with PD with or without agoraphobia participated in our study. All 77 patients received paroxetine (up to 40 mg per day) and 30/77 patients received paroxetine plus clonazepam (up to 1.5 mg/day) for the first 12 weeks of treatment. Patients were assigned to receive clonazepam in a non-randomized fashion. A gradual clonazepam taper was started after week 8, and the clonazepam was discontinued at week 12. The patients in both groups were then continued on paroxetine monotherapy for a total of 12 mont...

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