Binding of aminoglycoside antibiotics to helix 69 of 23S rRNA (original) (raw)
Binding of Neomycin-Class Aminoglycoside Antibiotics to Mutant Ribosomes with Alterations in the A Site of 16S rRNA
E. Westhof
Antimicrobial Agents and Chemotherapy, 2006
View PDFchevron_right
Antibacterial Aminoglycosides with a Modified Mode of Binding to the Ribosomal-RNA Decoding Site
Eric Westhof, Susanta Adhikari
Angewandte Chemie International Edition, 2007
View PDFchevron_right
Effect of mutations in the A site of 16 S rRNA on aminoglycoside antibiotic-ribosome interaction
Stephen Douthwaite
Journal of Molecular Biology, 1999
View PDFchevron_right
Aminoglycoside-Hybrid Ligands Targeting the Ribosomal Decoding Site
Klaus Simonsen
ChemBioChem, 2005
View PDFchevron_right
Aminoglycoside Association Pathways with the 30S Ribosomal Subunit
Joanna Trylska
The Journal of Physical Chemistry B, 2009
View PDFchevron_right
Design and Synthesis of Aminoglycoside Antibiotics to Selectively Target 16S Ribosomal RNA Position 1408
Erik Böttger
Helvetica Chimica Acta, 2005
View PDFchevron_right
Aminoglycoside antibiotics bound to aminoglycoside-detoxifying enzymes and RNA adopt similar conformations
Ayca Akal-Strader
Cell Biochemistry and Biophysics, 2000
View PDFchevron_right
rRNA Chemical Groups Required for Aminoglycoside Binding
Scott C. Blanchard
Biochemistry, 1998
View PDFchevron_right
Comparing aminoglycoside binding sites in bacterial ribosomal RNA and aminoglycoside modifying enzymes
Joanna Trylska
Proteins: Structure, Function, and Bioinformatics, 2012
View PDFchevron_right
The macrolide-ketolide antibiotic binding site is formed by structures in domains II and V of 23S ribosomal RNA
Stephen Douthwaite
Molecular Microbiology, 1999
View PDFchevron_right
Analysis of the Contribution of Individual Substituents in 4,6-Aminoglycoside-Ribosome Interaction
E. Westhof
Antimicrobial Agents and Chemotherapy, 2005
View PDFchevron_right
Erythromycin, Roxithromycin, and Clarithromycin: Use of Slow-Binding Kinetics to Compare Their in Vitro Interaction with a Bacterial Ribosomal Complex Active in Peptide Bond Formation
G. Dinos
Molecular Pharmacology, 2003
View PDFchevron_right
Binding thermodynamics of paromomycin, neomycin, neomycin-dinucleotide and -diPNA conjugates to bacterial and human rRNA
Javier Alguacil
Journal of molecular recognition : JMR, 2015
View PDFchevron_right
Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA
Maura Cannon
The Embo Journal, 1991
View PDFchevron_right
Modification at the 2′-Position of the 4,5-Series of 2-Deoxystreptamine Aminoglycoside Antibiotics To Resist Aminoglycoside Modifying Enzymes and Increase Ribosomal Target Selectivity
Andrea Vasella
ACS Infectious Diseases, 2019
View PDFchevron_right
Crystal Structure of a Complex between the Aminoglycoside Tobramycin and an Oligonucleotide Containing the Ribosomal Decoding A Site
Eric Westhof
Chemistry & Biology, 2002
View PDFchevron_right
Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA 1 1Edited by J. Karn
E. Westhof
Journal of Molecular Biology, 1998
View PDFchevron_right
Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: An analysis of x-ray crystal structures
Eric Westhof
Biopolymers, 2003
View PDFchevron_right
Aminoglycoside–RNA interactions
Eric Westhof
Current Opinion in Chemical Biology, 1999
View PDFchevron_right
Comparison of X-Ray Crystal Structure of the 30S Subunit-Antibiotic Complex with NMR Structure of Decoding Site Oligonucleotide-Paromomycin Complex
Ruben Gonzalez
Structure, 2003
View PDFchevron_right
Chemically related 4,5-linked aminoglycoside antibiotics drive subunit rotation in opposite directions
Sylvie Garneau-tsodikova
Nature communications, 2015
View PDFchevron_right
Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A
Manuel Juette, Thomas A Steitz, Yury Polikanov, George Dinos
Molecular cell, 2015
View PDFchevron_right
Association of Aminoglycosidic Antibiotics with the Ribosomal A-Site Studied with Brownian Dynamics
Joanna Trylska
Journal of Chemical Theory and Computation, 2008
View PDFchevron_right
Aminoglycoside binding to the hammerhead ribozyme: a general model for the interaction of cationic antibiotics with RNA
Eric Westhof
Journal of Molecular Biology, 1998
View PDFchevron_right
Chemical parameters influencing fine-tuning in the binding of macrolide antibiotics to the ribosomal tunnel
Erez Pyetan
View PDFchevron_right
Thermodynamic Studies of Aminoglycoside Antibiotic-Enzyme Interactions
Engin Serpersu
View PDFchevron_right
Dissociation–equilibrium constant and bound conformation for weak antibiotic binding interaction with different bacterial ribosomes
Pascale Mauvais
Journal of The Chemical Society-perkin Transactions 2, 2000
View PDFchevron_right
A Structural Basis for the Antibiotic Resistance Conferred by an A1408G Mutation in 16S rRNA and for the Antiprotozoal Activity of Aminoglycosides
Jiro Kondo
Angewandte Chemie International Edition, 2012
View PDFchevron_right
MicroReview Antibiotics and the ribosome
Alexander Mankin
2006
View PDFchevron_right
Effects of the 1-N-(4-Amino-2S-hydroxybutyryl) and 6′-N-(2-Hydroxyethyl) Substituents on Ribosomal Selectivity, Cochleotoxicity, and Antibacterial Activity in the Sisomicin Class of Aminoglycoside Antibiotics
Andrea Vasella
ACS Infectious Diseases, 2018
View PDFchevron_right
Structural signatures of antibiotic binding sites on the ribosome
hilda david-eden
Nucleic Acids Research, 2010
View PDFchevron_right
Erythromycin, Cethromycin and Solithromycin display similar binding affinities to the E. coli's ribosome: A molecular simulation study
HUYNH QUANG LINH
Journal of Molecular Graphics & Modelling, 2019
View PDFchevron_right
Free and bound state structures of 6-O-methyl homoerythromycins and epitope mapping of their interactions with ribosomes
Janez Plavec
Bioorganic & Medicinal Chemistry, 2009
View PDFchevron_right
Antibiotics Targeting Ribosomes: Crystallographic Studies
Francois Franceschi
Current Drug Target -Infectious Disorders, 2002
View PDFchevron_right